SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 ALA A 477
VAL A 493
TRP A 481
 None
 0.84A 1tkqB-4oxiA:
undetectable		 1tkqB-4oxiA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 12 GLN A 133
LEU A  49
ILE A 253
ILE A  94
ALA A  90
 None
 0.92A 2bxcA-4oxiA:
undetectable		 2bxcA-4oxiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 4 LEU A  49
ILE A 253
ILE A  94
ALA A  90
 None
 0.86A 2i30A-4oxiA:
undetectable		 2i30A-4oxiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 319
GLY A 317
GLY A 341
THR A 291
VAL A 289
 GAP  A 601 (-4.3A)
GAP  A 601 (-3.2A)
GAP  A 601 (-4.9A)
None
None
 0.82A 2okcA-4oxiA:
undetectable		 2okcA-4oxiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 10 ASP A 247
SER A 259
ILE A 258
PHE A 369
THR A 346
 GAP  A 601 (-2.8A)
None
None
None
None
 1.38A 2v0mA-4oxiA:
undetectable		 2v0mA-4oxiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 7 GLY A 317
GLY A 341
THR A 343
ARG A 457
 GAP  A 601 (-3.2A)
GAP  A 601 (-4.9A)
GAP  A 601 (-4.0A)
GAP  A 601 (-3.7A)
 0.35A 2wd9A-4oxiA:
36.3		 2wd9A-4oxiA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 8 GLY A 317
GLY A 341
THR A 343
ARG A 457
 GAP  A 601 (-3.2A)
GAP  A 601 (-4.9A)
GAP  A 601 (-4.0A)
GAP  A 601 (-3.7A)
 0.36A 2wd9B-4oxiA:
35.7		 2wd9B-4oxiA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 12 SER A  92
TYR A  56
LEU A  49
ILE A 253
LEU A 154
 None
 1.44A 2xkwA-4oxiA:
undetectable		 2xkwA-4oxiA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG A  33
VAL A 181
THR A  62
 None
 0.86A 3cyxA-4oxiA:
undetectable		 3cyxA-4oxiA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 GLU A 372
GLU A 387
TRP A 427
 None
 0.89A 3hrdA-4oxiA:
undetectable
3hrdE-4oxiA:
undetectable
3hrdF-4oxiA:
undetectable		 3hrdA-4oxiA:
21.27
3hrdE-4oxiA:
21.27
3hrdF-4oxiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 VAL A 440
VAL A 355
SER A 358
 None
 0.72A 3n8xB-4oxiA:
undetectable		 3n8xB-4oxiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 LYS A 187
SER A  67
GLN A 179
 None
 1.33A 3si7A-4oxiA:
undetectable		 3si7A-4oxiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 12 THR A 350
GLY A 341
GLY A 317
GLN A 403
GLU A 371
 None
GAP  A 601 (-4.9A)
GAP  A 601 (-3.2A)
None
None
 1.38A 3tkaA-4oxiA:
undetectable		 3tkaA-4oxiA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 8 HIS A  34
VAL A 185
VAL A 186
GLN A  41
 None
 1.01A 3uy4A-4oxiA:
undetectable		 3uy4A-4oxiA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 7 PHE A 246
ASP A 247
GLY A 317
THR A 343
LYS A 452
 GAP  A 601 (-4.5A)
GAP  A 601 (-2.8A)
GAP  A 601 (-3.2A)
GAP  A 601 (-4.0A)
GAP  A 601 (-2.8A)
 0.64A 3vnsA-4oxiA:
43.1		 3vnsA-4oxiA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 7 PHE A 246
ASP A 247
GLY A 317
THR A 343
LYS A 452
 GAP  A 601 (-4.5A)
GAP  A 601 (-2.8A)
GAP  A 601 (-3.2A)
GAP  A 601 (-4.0A)
GAP  A 601 (-2.8A)
 0.92A 4zxiA-4oxiA:
41.8		 4zxiA-4oxiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 5 GLN A 456
THR A 245
ASP A 243
ASN A 108
 None
 1.30A 5b2oA-4oxiA:
0.0		 5b2oA-4oxiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 5 GLN A 456
THR A 245
ASP A 243
ASN A 108
 None
 1.29A 5b2pA-4oxiA:
0.0		 5b2pA-4oxiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1729_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 5 GLN A 456
THR A 245
ASP A 243
ASN A 108
 None
 1.29A 5b2qA-4oxiA:
0.0		 5b2qA-4oxiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 4 LEU A  83
TYR A  91
PRO A 106
ILE A 105
 None
 1.14A 5esgA-4oxiA:
undetectable		 5esgA-4oxiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 6 LYS A 271
ARG A  86
ASP A 243
ASP A 252
 None
 1.30A 5hp1A-4oxiA:
undetectable		 5hp1A-4oxiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 4 LEU A 142
ARG A 148
ILE A 151
PHE A 171
 None
 1.12A 5kirB-4oxiA:
undetectable		 5kirB-4oxiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 12 LEU A 409
ALA A 122
ARG A  79
ILE A 105
LEU A 141
 None
 1.24A 5ljcA-4oxiA:
undetectable		 5ljcA-4oxiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 THR A 346
THR A 103
LEU A 409
 None
 0.59A 5m66D-4oxiA:
5.2		 5m66D-4oxiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		5 / 7 PHE A 246
ASP A 247
GLY A 317
GLY A 341
LYS A 452
 GAP  A 601 (-4.5A)
GAP  A 601 (-2.8A)
GAP  A 601 (-3.2A)
GAP  A 601 (-4.9A)
GAP  A 601 (-2.8A)
 0.95A 5n9xA-4oxiA:
44.3		 5n9xA-4oxiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		4 / 7 THR A 435
LEU A 441
VAL A 349
TYR A 340
 None
None
None
GAP  A 601 (-4.9A)
 1.12A 5ov9A-4oxiA:
undetectable		 5ov9A-4oxiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG A 446
LYS A 452
ARG A 110
 GAP  A 601 (-4.3A)
GAP  A 601 (-2.8A)
None
 1.07A 6c06D-4oxiA:
undetectable		 6c06D-4oxiA:
undetectable