SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 HIS A  64
GLY A 204
HIS A 137
ASP A 278
ASP A  62
 MN  A 401 (-3.4A)
None
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.19A 1a4lD-4oxrA:
undetectable		 1a4lD-4oxrA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 TYR A 167
ALA A  51
ILE A  53
ALA A 155
ILE A 113
 None
 0.87A 2h42B-4oxrA:
undetectable		 2h42B-4oxrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 5 ALA A 138
ILE A 122
ILE A 134
ASP A 135
 None
 1.09A 2h4jA-4oxrA:
undetectable		 2h4jA-4oxrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 5 PHE A 206
PHE A 209
PHE A 189
VAL A 275
 None
 1.23A 2lh6A-4oxrA:
2.1		 2lh6A-4oxrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 HIS A  64
GLY A 204
HIS A 137
SER A 254
ASP A 278
 MN  A 401 (-3.4A)
None
MN  A 401 (-3.4A)
None
MN  A 401 (-2.0A)
 1.29A 2pgfA-4oxrA:
undetectable		 2pgfA-4oxrA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 9 PHE A 209
PHE A 206
PHE A 189
ASN A 297
ILE A 301
 None
 1.39A 3t3rB-4oxrA:
undetectable		 3t3rB-4oxrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 6 HIS A 137
GLU A 252
ASP A 278
SER A 254
 MN  A 401 (-3.4A)
None
MN  A 401 (-2.0A)
None
 1.04A 4apjA-4oxrA:
undetectable
4apjP-4oxrA:
undetectable		 4apjA-4oxrA:
19.73
4apjP-4oxrA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 GLU A 252
ASP A 135
GLY A 204
SER A 202
GLN A 228
 None
 1.21A 4djeB-4oxrA:
undetectable		 4djeB-4oxrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 GLU A 252
ASP A 278
ASP A 135
GLY A 204
SER A 202
 None
MN  A 401 (-2.0A)
None
None
None
 1.15A 4djeB-4oxrA:
undetectable		 4djeB-4oxrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		5 / 12 GLU A 252
ASP A 278
LEU A 124
GLY A 204
SER A 202
 None
MN  A 401 (-2.0A)
None
None
None
 1.19A 4djfB-4oxrA:
undetectable		 4djfB-4oxrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		3 / 3 LYS A  71
LYS A  69
PRO A  70
 None
 1.25A 4dv1L-4oxrA:
undetectable		 4dv1L-4oxrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 6 TYR A 148
GLU A  90
THR A  35
LEU A  39
 None
 1.44A 4qztA-4oxrA:
undetectable		 4qztA-4oxrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 7 ILE A  83
HIS A  54
LEU A  76
ALA A  79
 None
 0.96A 5hrqE-4oxrA:
undetectable
5hrqF-4oxrA:
undetectable
5hrqJ-4oxrA:
undetectable		 5hrqE-4oxrA:
9.94
5hrqF-4oxrA:
7.53
5hrqJ-4oxrA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 6 ILE A  56
ALA A  75
LEU A  76
ILE A  82
 None
 0.82A 5mvmB-4oxrA:
undetectable
5mvmC-4oxrA:
undetectable		 5mvmB-4oxrA:
17.94
5mvmC-4oxrA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA
(Staphylococcus
pseudintermedius) 		4 / 6 PHE A  96
ASN A  85
LEU A  89
GLY A  92
 None
 1.01A 5o4yA-4oxrA:
undetectable		 5o4yA-4oxrA:
5.46