SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4oxx CINDOXIN
(Citrobacter
braakii) 		6 / 7 THR A  11
ASN A  13
THR A  58
GLY A  93
ASP A  94
TYR A  97
 FMN  A 200 (-3.4A)
FMN  A 200 (-3.5A)
FMN  A 200 (-3.8A)
FMN  A 200 (-3.1A)
None
FMN  A 200 (-3.5A)
 0.90A 1bu5A-4oxxA:
20.5		 1bu5A-4oxxA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4oxx CINDOXIN
(Citrobacter
braakii) 		6 / 8 THR A  11
ASN A  13
THR A  58
GLY A  93
ASP A  94
TYR A  97
 FMN  A 200 (-3.4A)
FMN  A 200 (-3.5A)
FMN  A 200 (-3.8A)
FMN  A 200 (-3.1A)
None
FMN  A 200 (-3.5A)
 0.85A 1bu5B-4oxxA:
20.7		 1bu5B-4oxxA:
33.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4oxx CINDOXIN
(Citrobacter
braakii) 		6 / 11 ALA A  18
ILE A 144
VAL A  33
LEU A  92
THR A 122
ALA A 123
 None
None
None
FMN  A 200 ( 4.3A)
None
None
 1.24A 1rv7A-4oxxA:
undetectable
1rv7B-4oxxA:
undetectable		 1rv7A-4oxxA:
20.25
1rv7B-4oxxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 10 LEU A  82
LEU A  45
ILE A  52
PHE A  71
THR A  78
 None
 1.12A 2w9gA-4oxxA:
2.5		 2w9gA-4oxxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4oxx CINDOXIN
(Citrobacter
braakii) 		4 / 8 ALA A 134
PHE A  90
ILE A  21
THR A  20
 None
 0.89A 3bpxA-4oxxA:
undetectable
3bpxB-4oxxA:
undetectable		 3bpxA-4oxxA:
19.14
3bpxB-4oxxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 12 LEU A  82
LEU A  45
ILE A  52
PHE A  71
THR A  78
 None
 1.12A 3fl9B-4oxxA:
undetectable		 3fl9B-4oxxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 9 LEU A  82
LEU A  45
ILE A  52
PHE A  71
THR A  78
 None
 1.16A 3freX-4oxxA:
2.2		 3freX-4oxxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 11 LEU A  82
LEU A  45
ILE A  52
PHE A  71
THR A  78
 None
 1.10A 3jw5A-4oxxA:
2.3		 3jw5A-4oxxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 10 LEU A  82
LEU A  45
ILE A  52
PHE A  71
THR A  78
 None
 1.18A 3jw5B-4oxxA:
2.2		 3jw5B-4oxxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4oxx CINDOXIN
(Citrobacter
braakii) 		4 / 4 LEU A  36
GLY A  67
GLY A   8
THR A  56
 None
 0.83A 3si7A-4oxxA:
undetectable		 3si7A-4oxxA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 12 MET A   1
VAL A  29
LEU A  51
ALA A 141
LEU A 145
 None
 1.17A 4m11C-4oxxA:
undetectable		 4m11C-4oxxA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 12 MET A   1
VAL A  29
LEU A  51
ALA A 141
LEU A 145
 None
 1.13A 4m11D-4oxxA:
undetectable		 4m11D-4oxxA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 11 THR A  19
THR A  20
GLY A  12
ALA A  14
THR A   9
 None
None
FMN  A 200 (-3.9A)
FMN  A 200 (-3.3A)
FMN  A 200 (-3.6A)
 1.46A 4qwuV-4oxxA:
undetectable
4qwub-4oxxA:
undetectable		 4qwuV-4oxxA:
23.65
4qwub-4oxxA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oxx CINDOXIN
(Citrobacter
braakii) 		5 / 11 THR A  19
THR A  20
GLY A  12
ALA A  14
THR A   9
 None
None
FMN  A 200 (-3.9A)
FMN  A 200 (-3.3A)
FMN  A 200 (-3.6A)
 1.46A 4qwuH-4oxxA:
undetectable
4qwuN-4oxxA:
undetectable		 4qwuH-4oxxA:
23.65
4qwuN-4oxxA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4oxx CINDOXIN
(Citrobacter
braakii) 		4 / 7 THR A  74
LEU A  75
THR A  40
THR A  78
 None
 0.92A 4z91F-4oxxA:
undetectable
4z91G-4oxxA:
undetectable
4z91H-4oxxA:
undetectable
4z91I-4oxxA:
undetectable
4z91J-4oxxA:
undetectable		 4z91F-4oxxA:
20.06
4z91G-4oxxA:
20.06
4z91H-4oxxA:
20.06
4z91I-4oxxA:
20.06
4z91J-4oxxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4oxx CINDOXIN
(Citrobacter
braakii) 		4 / 7 THR A  78
THR A  74
LEU A  75
THR A  40
 None
 0.91A 4z91F-4oxxA:
undetectable
4z91G-4oxxA:
undetectable
4z91H-4oxxA:
undetectable
4z91I-4oxxA:
undetectable
4z91J-4oxxA:
undetectable		 4z91F-4oxxA:
20.06
4z91G-4oxxA:
20.06
4z91H-4oxxA:
20.06
4z91I-4oxxA:
20.06
4z91J-4oxxA:
20.06