SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 585
GLY A 586
LEU A 566
MET A 547
VAL A 658
 None
 1.16A 1fduC-4oy2A:
undetectable		 1fduC-4oy2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		3 / 3 GLU B 213
ASP B 211
TYR B 270
 None
 0.78A 2yvlB-4oy2B:
undetectable		 2yvlB-4oy2B:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		5 / 7 VAL B 292
LEU B 296
TYR B 288
ILE B 227
ASN B 230
 None
 1.23A 3avpA-4oy2B:
undetectable		 3avpA-4oy2B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 756
PHE A 480
LYS A 559
 None
 1.21A 3bjwG-4oy2A:
undetectable		 3bjwG-4oy2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 875
ASP A 817
GLU A 551
 None
 0.75A 3qowA-4oy2A:
undetectable		 3qowA-4oy2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		4 / 7 VAL B 272
GLY B 264
ILE B 265
VAL A 658
 None
 0.62A 3ufnB-4oy2B:
undetectable		 3ufnB-4oy2B:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 MET A 562
ILE A 619
HIS A 494
VAL A 485
GLU B 172
 None
 1.13A 3w1wB-4oy2A:
undetectable		 3w1wB-4oy2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 662
GLY A 824
THR A 875
ILE A 872
 None
 0.89A 4ejjA-4oy2A:
undetectable		 4ejjA-4oy2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR A 819
ARG B 276
SER A 882
HIS A 879
 None
 1.43A 4o4dA-4oy2A:
undetectable		 4o4dA-4oy2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 LYS A 507
ASP B 137
ASN B 131
SER B 142
 None
 1.11A 4obwB-4oy2A:
0.0		 4obwB-4oy2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B 178
LYS B 175
LEU A 536
 None
 1.05A 4ptjA-4oy2B:
undetectable		 4ptjA-4oy2B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		5 / 12 LYS A 565
ASN B 181
GLU A 757
HIS A 469
VAL A 526
 None
 1.28A 4ygfE-4oy2A:
undetectable		 4ygfE-4oy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		5 / 11 LYS A 565
ASN B 181
GLU A 757
HIS A 469
VAL A 526
 None
 1.23A 4yhaD-4oy2A:
undetectable		 4yhaD-4oy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 875
ASP A 817
GLU A 551
 None
 0.86A 5fa8A-4oy2A:
undetectable		 5fa8A-4oy2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLN A 489
VAL B 170
SER B 189
PRO A 554
LEU A 557
 None
 1.38A 5jh7D-4oy2A:
undetectable		 5jh7D-4oy2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 238
PHE A 498
SER A 639
ASN A 645
 None
 1.22A 5l1fC-4oy2B:
undetectable		 5l1fC-4oy2B:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 VAL B 293
VAL A 940
TYR A 778
GLN A 942
 None
 1.23A 5qgpA-4oy2B:
undetectable		 5qgpA-4oy2B:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 VAL B 293
VAL A 940
TYR A 778
GLN A 942
 None
 1.22A 5qgqA-4oy2B:
undetectable		 5qgqA-4oy2B:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 VAL B 293
VAL A 940
TYR A 778
GLN A 942
 None
 1.21A 5qhbA-4oy2B:
undetectable		 5qhbA-4oy2B:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 504
GLY A 505
THR A 506
LYS A 507
 None
 1.09A 5x23A-4oy2A:
undetectable		 5x23A-4oy2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 504
GLY A 505
THR A 506
LYS A 507
 None
 0.95A 5x24A-4oy2A:
undetectable		 5x24A-4oy2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 504
GLY A 505
THR A 506
LYS A 507
 None
 0.98A 5xxiA-4oy2A:
undetectable		 5xxiA-4oy2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 824
THR A 819
CYH A 821
GLY A 822
PRO A 818
 None
 1.17A 5ybbA-4oy2A:
undetectable		 5ybbA-4oy2A:
21.29