SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 11 ILE A  62
LEU A  31
MET A  35
LEU A  38
MET A  50
 None
 0.74A 1dtlA-4oy4A:
2.7		 1dtlA-4oy4A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 11 LEU A  31
MET A  35
LEU A  38
MET A  50
VAL A  54
 None
 0.58A 1dtlA-4oy4A:
2.7		 1dtlA-4oy4A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		4 / 4 THR A  28
LEU A  31
VAL A  34
LEU A  38
 None
 0.50A 1fbmD-4oy4A:
undetectable		 1fbmD-4oy4A:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 4 THR A  28
LEU A  31
VAL A  34
LEU A  38
 None
 0.84A 1mz9D-4oy4A:
undetectable		 1mz9D-4oy4A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 4 ASP A 295
LEU A 169
LEU A 377
LEU A 168
 None
 1.24A 1u18A-4oy4A:
undetectable		 1u18A-4oy4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 12 GLU A 219
ARG A 306
MET A 254
GLY A 267
LEU A 282
 CR8  A 303 ( 3.6A)
CR8  A 303 ( 2.9A)
None
None
None
 1.03A 2jfaB-4oy4A:
undetectable		 2jfaB-4oy4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		5 / 9 ALA A 343
VAL A 358
GLY A 256
ILE A 296
ALA A 300
 None
 0.93A 2z0yB-4oy4A:
undetectable		 2z0yB-4oy4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		6 / 12 SER A 332
PHE A 180
GLY A 162
THR A 161
THR A 183
GLU A 151
 GOL  A 504 ( 3.9A)
None
None
None
GOL  A 504 (-2.8A)
None
 1.35A 2zifA-4oy4A:
undetectable		 2zifA-4oy4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 4 GLU A 330
ARG A 344
ASN A 345
ASP A 346
 GOL  A 504 (-4.7A)
None
CR8  A 303 ( 4.1A)
None
 1.46A 2zq9A-4oy4A:
undetectable		 2zq9A-4oy4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		3 / 3 HIS A 220
GLU A 219
HIS A 201
 GOL  A 503 (-3.8A)
CR8  A 303 ( 3.6A)
CR8  A 303 ( 3.8A)
 0.77A 3ba0A-4oy4A:
undetectable		 3ba0A-4oy4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 12 GLY A 260
MET A 254
CYH A 341
VAL A 371
PHE A 365
 None
 1.50A 3gn8B-4oy4A:
undetectable		 3gn8B-4oy4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 7 GLU A 151
HIS A 197
VAL A 309
ALA A 221
 None
 1.06A 3kp6B-4oy4A:
undetectable		 3kp6B-4oy4A:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 8 PHE A  67
ILE A  62
LEU A  31
MET A  35
MET A  50
 None
 0.92A 4rjdA-4oy4A:
5.3		 4rjdA-4oy4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		4 / 4 SER A 386
ASP A 200
ASP A 163
ASP A  79
 None
 1.39A 4uciA-4oy4A:
undetectable		 4uciA-4oy4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		4 / 4 SER A 386
ASP A 200
ASP A 163
ASP A  79
 None
 1.40A 4uciB-4oy4A:
0.0		 4uciB-4oy4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		3 / 3 ASP A 346
ARG A 306
ARG A 331
 None
CR8  A 303 ( 2.9A)
CR8  A 303 ( 3.0A)
 0.95A 4x5iA-4oy4A:
undetectable		 4x5iA-4oy4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 10 TYR A 184
ARG A 331
VAL A 307
TYR A 311
ILE A 203
 None
CR8  A 303 ( 3.0A)
None
None
CR8  A 303 ( 3.7A)
 1.33A 5hw8C-4oy4A:
undetectable
5hw8H-4oy4A:
undetectable		 5hw8C-4oy4A:
15.59
5hw8H-4oy4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		5 / 12 THR A 298
MET A 166
PHE A 180
ILE A 164
THR A 182
 None
CR8  A 303 ( 3.4A)
None
CR8  A 303 ( 4.7A)
None
 1.25A 5w8aA-4oy4A:
undetectable		 5w8aA-4oy4A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 9 GLU A 219
ARG A 306
MET A 254
GLY A 267
LEU A 282
 CR8  A 303 ( 3.6A)
CR8  A 303 ( 2.9A)
None
None
None
 1.48A 5wgqA-4oy4A:
undetectable		 5wgqA-4oy4A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 6 PHE A 365
PRO A 366
GLY A 369
ASN A 368
 None
 0.79A 5x24A-4oy4A:
undetectable		 5x24A-4oy4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		3 / 3 TYR A 154
ASP A  49
ASP A 163
 None
 0.81A 5x6yA-4oy4A:
undetectable		 5x6yA-4oy4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		4 / 5 THR A 384
ASP A  77
GLU A  46
ASN A  41
 None
 1.46A 5ybbA-4oy4A:
undetectable		 5ybbA-4oy4A:
22.31