SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.91A 1v55C-4oyaA:
undetectable
1v55J-4oyaA:
undetectable
1v55C-4oyaA:
19.62
1v55J-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.02A 2dysP-4oyaA:
undetectable
2dysW-4oyaA:
undetectable
2dysP-4oyaA:
19.62
2dysW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.92A 2eijC-4oyaA:
undetectable
2eijJ-4oyaA:
undetectable
2eijC-4oyaA:
19.62
2eijJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.95A 2eikC-4oyaA:
undetectable
2eikJ-4oyaA:
undetectable
2eikC-4oyaA:
19.62
2eikJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.97A 2eimC-4oyaA:
undetectable
2eimJ-4oyaA:
undetectable
2eimC-4oyaA:
19.62
2eimJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.93A 2einC-4oyaA:
undetectable
2einJ-4oyaA:
undetectable
2einC-4oyaA:
19.62
2einJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.91A 2einP-4oyaA:
undetectable
2einW-4oyaA:
undetectable
2einP-4oyaA:
19.62
2einW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 PHE A 348
GLY A 434
THR A 293
SER A 388
GLY A 464
None
0.92A 2hw2A-4oyaA:
undetectable
2hw2A-4oyaA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 5 LEU A 325
ILE A 321
ILE A 369
ALA A 366
GOL  A 502 (-4.3A)
None
None
None
0.73A 2i2zA-4oyaA:
undetectable
2i2zA-4oyaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 ASP A  99
THR A  52
ILE A  79
ASN A  76
1VE  A 501 (-2.5A)
None
None
None
1.14A 2jc9A-4oyaA:
undetectable
2jc9A-4oyaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 GLY A 330
GLN A 331
HIS A 164
TYR A 318
HIS A 162
None
GOL  A 502 (-3.7A)
None
None
GOL  A 502 (-4.1A)
1.19A 2prgA-4oyaA:
undetectable
2prgA-4oyaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 ALA A 182
ASN A 185
ILE A 204
ILE A 202
ASN A 216
None
1.05A 2rlcA-4oyaA:
undetectable
2rlcA-4oyaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 8 ILE A 407
ASN A 412
ARG A 176
SER A  49
None
None
1VE  A 501 (-3.2A)
None
1.04A 2zw9B-4oyaA:
undetectable
2zw9B-4oyaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.93A 2zxwP-4oyaA:
undetectable
2zxwW-4oyaA:
undetectable
2zxwP-4oyaA:
19.62
2zxwW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 5 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.01A 3ablC-4oyaA:
undetectable
3ablJ-4oyaA:
undetectable
3ablC-4oyaA:
19.62
3ablJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.98A 3ablP-4oyaA:
undetectable
3ablW-4oyaA:
undetectable
3ablP-4oyaA:
19.62
3ablW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
0.98A 3ag1C-4oyaA:
undetectable
3ag1J-4oyaA:
undetectable
3ag1C-4oyaA:
19.62
3ag1J-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 CYH A 122
ILE A 115
LEU A 147
VAL A 187
TYR A 240
None
1.19A 3sp9A-4oyaA:
undetectable
3sp9A-4oyaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 LEU A  75
THR A  55
THR A 405
GLY A  98
None
0.94A 4eq4A-4oyaA:
undetectable
4eq4A-4oyaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 5 ILE A 277
PRO A  12
TYR A  26
VAL A  25
None
1.36A 4s0vA-4oyaA:
undetectable
4s0vA-4oyaA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4USW_A_ACTA1469_0
(ADENYLATE CYCLASE
TYPE 10)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 4 LYS A  95
HIS A 164
LYS A 334
VAL A 335
1VE  A 501 (-3.8A)
None
None
None
0.42A 4uswA-4oyaA:
59.9
4uswA-4oyaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 6 LYS A  95
LEU A 102
LEU A 166
VAL A 167
PHE A 336
1VE  A 501 (-3.8A)
1VE  A 501 (-3.6A)
1VE  A 501 (-3.9A)
1VE  A 501 (-3.7A)
1VE  A 501 (-3.9A)
0.57A 4uswA-4oyaA:
59.9
4uswA-4oyaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.01A 5b1bC-4oyaA:
undetectable
5b1bJ-4oyaA:
undetectable
5b1bC-4oyaA:
19.62
5b1bJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 GLY A 330
GLN A 331
HIS A 164
TYR A 318
HIS A 162
None
GOL  A 502 (-3.7A)
None
None
GOL  A 502 (-4.1A)
1.16A 5ji0D-4oyaA:
undetectable
5ji0D-4oyaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 VAL A 167
ARG A  33
ILE A 314
PHE A 157
1VE  A 501 (-3.7A)
None
None
None
1.05A 5jw1B-4oyaA:
undetectable
5jw1B-4oyaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 LEU A 345
LYS A 334
GLY A  98
ALA A 414
VAL A 391
None
1.28A 5kbwB-4oyaA:
undetectable
5kbwB-4oyaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 4 LEU A 166
ARG A  33
ILE A 314
PHE A 157
1VE  A 501 (-3.9A)
None
None
None
1.09A 5kirB-4oyaA:
undetectable
5kirB-4oyaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 11 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
1.01A 5lg3A-4oyaA:
undetectable
5lg3A-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.97A 5lg3E-4oyaA:
undetectable
5lg3E-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 10 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.98A 5lg3F-4oyaA:
undetectable
5lg3F-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 10 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.99A 5lg3G-4oyaA:
undetectable
5lg3G-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 10 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.97A 5lg3H-4oyaA:
0.1
5lg3H-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 9 ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.90A 5lg3I-4oyaA:
undetectable
5lg3I-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.97A 5lg3J-4oyaA:
undetectable
5lg3J-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 5 ALA A  97
VAL A 406
PHE A 336
ILE A 294
1VE  A 501 (-3.1A)
None
1VE  A 501 (-3.9A)
None
0.91A 5of1B-4oyaA:
undetectable
5of1B-4oyaA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 HIS A  19
ASN A 333
LEU A 274
GLN A 331
None
None
None
GOL  A 502 (-3.7A)
1.44A 5xdhA-4oyaA:
undetectable
5xdhC-4oyaA:
undetectable
5xdhA-4oyaA:
12.86
5xdhC-4oyaA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.08A 5z84P-4oyaA:
undetectable
5z84W-4oyaA:
undetectable
5z84P-4oyaA:
19.62
5z84W-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.11A 5z85P-4oyaA:
undetectable
5z85W-4oyaA:
undetectable
5z85P-4oyaA:
19.62
5z85W-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.01A 5z86C-4oyaA:
undetectable
5z86J-4oyaA:
undetectable
5z86C-4oyaA:
19.62
5z86J-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.04A 5z86P-4oyaA:
undetectable
5z86W-4oyaA:
undetectable
5z86P-4oyaA:
19.62
5z86W-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.07A 5zcpC-4oyaA:
undetectable
5zcpJ-4oyaA:
undetectable
5zcpC-4oyaA:
19.62
5zcpJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.10A 5zcpP-4oyaA:
undetectable
5zcpW-4oyaA:
undetectable
5zcpP-4oyaA:
19.62
5zcpW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
5 / 12 ILE A 145
ILE A  82
VAL A  86
LEU A 147
VAL A 175
None
1.16A 6ajiA-4oyaA:
5.6
6ajiA-4oyaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 4 ILE A 384
LEU A 299
HIS A 320
ALA A 317
None
0.86A 6ck2C-4oyaA:
undetectable
6ck2D-4oyaA:
undetectable
6ck2C-4oyaA:
4.15
6ck2D-4oyaA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
3 / 3 TYR A  26
ALA A  17
LEU A 255
None
CME  A 253 ( 4.4A)
None
0.75A 6d9kF-4oyaA:
undetectable
6d9kF-4oyaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 7 ILE A  82
GLU A 131
HIS A 127
VAL A 143
None
1.08A 6j20A-4oyaA:
undetectable
6j20A-4oyaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4oya ADENYLATE CYCLASE
TYPE 10

(Homo
sapiens)
4 / 6 GLN A 375
PHE A 372
LEU A 299
PHE A 301
None
1.03A 6nmpC-4oyaA:
undetectable
6nmpJ-4oyaA:
undetectable
6nmpC-4oyaA:
19.62
6nmpJ-4oyaA:
8.46