SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		5 / 8 MET B  53
GLU A  67
GLU B 109
ASP B 105
ARG B 101
 None
 1.33A 1dtlA-4oydB:
undetectable		 1dtlA-4oydB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.34A 1gwrA-4oydA:
undetectable		 1gwrA-4oydA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4oyd COMPUTATIONALLY
DESIGNED INHIBITOR
(synthetic
construct) 		3 / 3 GLU B  70
LYS B   4
VAL B   6
 None
 0.95A 1l2iA-4oydB:
2.3		 1l2iA-4oydB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.27A 1pcgA-4oydA:
2.2		 1pcgA-4oydA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.27A 1pcgB-4oydA:
2.2		 1pcgB-4oydA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		4 / 4 LEU A  53
SER A  97
ASP A 156
ASP B  72
 None
 1.28A 2br4B-4oydA:
undetectable		 2br4B-4oydA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		5 / 10 LYS B  96
GLU B  93
ILE B  64
GLU A  56
LYS B  68
 None
 1.47A 2j9dD-4oydB:
undetectable
2j9dE-4oydB:
undetectable
2j9dF-4oydB:
undetectable		 2j9dD-4oydB:
21.17
2j9dE-4oydB:
21.17
2j9dF-4oydB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.27A 2ocfA-4oydA:
1.8		 2ocfA-4oydA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A  58
SER A  62
THR A  66
GLU A  63
HIS A 110
 None
 1.33A 3r75A-4oydA:
undetectable		 3r75A-4oydA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A  58
SER A  62
THR A  66
GLU A  63
HIS A 110
 None
 1.32A 3r75B-4oydA:
undetectable		 3r75B-4oydA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		5 / 12 PHE A  87
ILE A  57
THR A   5
ALA B  56
ALA B  51
 None
 1.23A 3ua1A-4oydA:
undetectable		 3ua1A-4oydA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 LEU A  54
ILE A 154
GLY A  99
ILE A  57
ALA A 101
 None
 1.20A 3uj7A-4oydA:
undetectable		 3uj7A-4oydA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 LEU A  54
ILE A 154
GLY A  99
ILE A  57
ALA A 101
 None
 1.18A 3uj7B-4oydA:
undetectable		 3uj7B-4oydA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 11 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.29A 3uudA-4oydA:
undetectable		 3uudA-4oydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.29A 5dxeB-4oydA:
undetectable		 5dxeB-4oydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A 144
GLY A 149
THR A 152
TYR A  50
LEU A 140
 None
 1.11A 5hw4A-4oydA:
undetectable		 5hw4A-4oydA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A 144
GLY A 149
THR A 152
TYR A  50
LEU A 140
 None
 1.15A 5hw4C-4oydA:
undetectable		 5hw4C-4oydA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  31
ALA A  33
LEU A  10
HIS A  26
LEU A  25
 None
 1.31A 5hyrA-4oydA:
undetectable		 5hyrA-4oydA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A 154
LEU A  98
LEU A  12
ILE A   8
GLY A 139
 None
 1.09A 5ienA-4oydA:
undetectable		 5ienA-4oydA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4oyd COMPUTATIONALLY
DESIGNED INHIBITOR
(synthetic
construct) 		3 / 3 LYS B  68
ASP B  72
ARG B  65
 None
 1.01A 5jwaA-4oydB:
undetectable
5jwaH-4oydB:
undetectable		 5jwaA-4oydB:
12.80
5jwaH-4oydB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		4 / 6 ALA B  63
GLN B  66
GLN B  69
ASP A 156
 None
 1.47A 5y9aA-4oydB:
undetectable		 5y9aA-4oydB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4oyd APOPTOSIS REGULATOR
BHRF1
(Human
gammaherpesvirus
4) 		5 / 12 ILE A   8
ALA A  11
LEU A  40
ILE A 154
LEU A  54
 None
 0.98A 6a5zD-4oydA:
undetectable		 6a5zD-4oydA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR
(Human
gammaherpesvirus
4;
synthetic
construct) 		4 / 8 SER B 100
ARG A  60
ASN A  61
ASP B 105
 None
 1.28A 6auuB-4oydB:
undetectable		 6auuB-4oydB:
14.45