SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.01A 1cqeA-4oyeA:
1.8		 1cqeA-4oyeA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.02A 1cqeB-4oyeA:
undetectable		 1cqeB-4oyeA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 TYR A  88
LEU A 250
VAL A 400
ASP A 312
 None
 1.23A 1dz6A-4oyeA:
undetectable		 1dz6A-4oyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 2aylA-4oyeA:
undetectable		 2aylA-4oyeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.01A 2aylB-4oyeA:
undetectable		 2aylB-4oyeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ILE A  61
ALA A 191
GLU A 296
THR A 154
ILE A 155
 None
 1.19A 2w3aA-4oyeA:
undetectable		 2w3aA-4oyeA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ILE A  61
ALA A 191
GLU A 296
THR A 154
ILE A 155
 None
 1.24A 2w3aB-4oyeA:
undetectable		 2w3aB-4oyeA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 160
PHE A 261
ALA A 265
ALA A 268
THR A 281
 None
 1.30A 2x2nD-4oyeA:
undetectable		 2x2nD-4oyeA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.02A 3n8wA-4oyeA:
undetectable		 3n8wA-4oyeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.05A 3n8zA-4oyeA:
1.8		 3n8zA-4oyeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 3n8zB-4oyeA:
undetectable		 3n8zB-4oyeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.10A 3pghD-4oyeA:
undetectable		 3pghD-4oyeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 ASN A 401
ALA A 397
GLY A 313
THR A 314
 None
 1.15A 4bboC-4oyeA:
undetectable		 4bboC-4oyeA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 TYR A  88
THR A 403
LEU A 250
ASP A 312
 None
 1.10A 4l4dA-4oyeA:
undetectable		 4l4dA-4oyeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 TYR A  88
THR A 403
LEU A 250
ASP A 312
 None
 1.07A 4l4eA-4oyeA:
undetectable		 4l4eA-4oyeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 TYR A  88
THR A 403
LEU A 250
ASP A 312
 None
 1.07A 4l4fA-4oyeA:
undetectable		 4l4fA-4oyeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 GLU A 291
MET A 399
VAL A 402
THR A 403
 None
 1.15A 4lnwA-4oyeA:
undetectable		 4lnwA-4oyeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.04A 4otyB-4oyeA:
undetectable		 4otyB-4oyeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.05A 4rs0A-4oyeA:
undetectable		 4rs0A-4oyeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A 198
LEU A  57
LEU A  54
PHE A  50
THR A 271
 None
 1.33A 4zmeB-4oyeA:
undetectable		 4zmeB-4oyeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 5ikqA-4oyeA:
undetectable		 5ikqA-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.11A 5ikrA-4oyeA:
undetectable		 5ikrA-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.01A 5ikrB-4oyeA:
undetectable		 5ikrB-4oyeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.07A 5kirA-4oyeA:
undetectable		 5kirA-4oyeA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A 176
GLU A 174
SER A 171
LEU A 168
ASN A 170
 None
 1.20A 5x6yB-4oyeA:
undetectable		 5x6yB-4oyeA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 387
ASP A 390
ASP A 394
GLN A 318
 None
 1.36A 6g31D-4oyeA:
undetectable		 6g31D-4oyeA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A 387
ASP A 390
ASP A 394
GLN A 318
 None
 1.32A 6g31J-4oyeA:
undetectable		 6g31J-4oyeA:
12.07