SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ozt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU E 481
ALA U 349
ILE E 292
ILE E 435
 None
 1.01A 1crbA-4oztE:
undetectable		 1crbA-4oztE:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU E 481
LEU U 353
ALA U 349
ILE E 292
 None
 0.95A 1crbA-4oztE:
undetectable		 1crbA-4oztE:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 6 ALA U 244
SER E 439
ARG U 326
LEU U 241
 None
 1.14A 1gahA-4oztU:
undetectable		 1gahA-4oztU:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU U 355
LEU U 358
LEU U 242
LEU U 300
ILE U 306
 None
 1.09A 1s9pD-4oztU:
19.4		 1s9pD-4oztU:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 6 PRO E 442
PHE U 246
ILE U 361
SER U 247
 None
 1.19A 1sbrA-4oztE:
undetectable
1sbrB-4oztE:
undetectable		 1sbrA-4oztE:
21.90
1sbrB-4oztE:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU U 212
LEU U 209
ILE U 307
ILE U 380
LEU U 384
 None
 0.86A 1tw4A-4oztU:
undetectable		 1tw4A-4oztU:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		5 / 10 LEU E 364
ALA E 346
LEU E 349
ASP E 359
LEU E 355
 None
 1.10A 1yi4A-4oztE:
undetectable		 1yi4A-4oztE:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU E 432
LEU E 431
ALA E 434
LEU E 458
CYH E 367
 None
 1.36A 2aa6A-4oztE:
21.7		 2aa6A-4oztE:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU U 233
LEU U 225
ILE U 307
SER U 224
VAL U 329
 None
 1.32A 2pnjB-4oztU:
undetectable		 2pnjB-4oztU:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 ALA U 245
LEU U 358
ARG U 359
ILE U 278
LEU U 286
 None
 1.16A 3k2hA-4oztU:
undetectable		 3k2hA-4oztU:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 6 LEU U 242
LYS U 373
PHE U 370
GLY U 274
 None
None
None
NEQ  U 401 (-4.9A)
 1.01A 3sj1X-4oztU:
undetectable		 3sj1X-4oztU:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		4 / 5 PHE E 345
TYR E 429
LEU E 337
ARG E 379
 None
 1.41A 3sudD-4oztE:
undetectable		 3sudD-4oztE:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 LEU E 508
PRO E 509
LEU E 512
 None
 0.49A 3w1wB-4oztE:
undetectable		 3w1wB-4oztE:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 4 VAL U 339
THR U 337
GLU U 335
GLU U 334
 None
 1.34A 4l78A-4oztU:
undetectable		 4l78A-4oztU:
10.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 ILE E 331
MET E 372
ARG E 375
 P1A  E 601 (-4.4A)
P1A  E 601 (-4.0A)
P1A  E 601 (-3.9A)
 0.94A 4lnwA-4oztE:
25.3		 4lnwA-4oztE:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU U 303
ARG U 304
PHE U 370
ALA U 245
SER U 247
 None
 1.07A 4o1zB-4oztU:
undetectable		 4o1zB-4oztU:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 LEU E 413
MET E 373
TYR E 420
 None
P1A  E 601 ( 4.4A)
None
 0.63A 4p6xG-4oztE:
22.3		 4p6xG-4oztE:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 PRO E 509
LEU E 512
GLN E 340
 None
 0.73A 4pevB-4oztE:
undetectable		 4pevB-4oztE:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU E 481
ALA U 349
ILE E 292
ILE E 435
 None
 1.00A 5h8tA-4oztE:
undetectable		 5h8tA-4oztE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU U 353
ALA U 349
ILE E 292
ILE E 435
 None
 1.05A 5hbsA-4oztE:
undetectable		 5hbsA-4oztE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU E 481
LEU U 353
ALA U 349
ILE E 435
 None
 0.76A 5ljeA-4oztE:
undetectable		 5ljeA-4oztE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR
(Pediculus
humanus;
Pediculus
humanus) 		5 / 12 PHE E 477
LEU E 481
LEU U 353
ALA U 349
TYR E 457
 None
 0.96A 5ljeA-4oztE:
undetectable		 5ljeA-4oztE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		3 / 3 LEU U 209
LEU U 212
TRP U 215
 None
 0.94A 5nwuA-4oztU:
undetectable		 5nwuA-4oztU:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 6 LEU U 308
SER U 305
PHE U 309
HIS U 221
 None
 1.10A 5om3A-4oztU:
undetectable
5om3B-4oztU:
undetectable		 5om3A-4oztU:
17.65
5om3B-4oztU:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		4 / 8 PHE U 279
HIS U 266
VAL U 253
SER U 250
 None
 1.22A 6huoC-4oztU:
2.8
6huoD-4oztU:
3.1		 6huoC-4oztU:
17.39
6huoD-4oztU:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4ozt RETINOID X RECEPTOR
(Pediculus
humanus) 		5 / 12 LEU U 369
ILE U 361
ALA U 273
ARG U 267
LEU U 259
 None
 1.31A 6ie8A-4oztU:
3.5		 6ie8A-4oztU:
22.28