SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ozv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		4 / 6 TRP A 208
PHE A 270
VAL A 357
PRO A  32
 None
 1.45A 3n6dA-4ozvA:
undetectable
3n6dB-4ozvA:
undetectable		 3n6dA-4ozvA:
20.96
3n6dB-4ozvA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  30
GLU A 229
ALA A 226
TRP A 191
ALA A 206
 None
 0.94A 3ou6C-4ozvA:
undetectable		 3ou6C-4ozvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 264
LEU A 261
TYR A 328
ALA A 234
ALA A 233
 None
 1.04A 3vw7A-4ozvA:
undetectable		 3vw7A-4ozvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 263
ALA A 207
GLU A 246
PHE A 230
LEU A 286
 None
 1.47A 4la0A-4ozvA:
1.4		 4la0A-4ozvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 PRO A 263
ALA A 207
GLU A 246
PHE A 230
LEU A 286
 None
 1.45A 4la0B-4ozvA:
1.4		 4la0B-4ozvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A  95
ALA A 147
GLY A 149
SER A 150
TYR A  36
 None
 1.20A 5vlmF-4ozvA:
1.4		 5vlmF-4ozvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		4 / 5 MET A 122
TYR A 155
GLY A 153
GLY A 354
 None
 1.16A 5x7pA-4ozvA:
undetectable		 5x7pA-4ozvA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4ozv ALGINATE LYASE
(Pseudomonas
aeruginosa) 		5 / 6 MET A 122
GLU A 177
TYR A 155
GLY A 153
GLY A 354
 None
 1.44A 5x7pB-4ozvA:
undetectable		 5x7pB-4ozvA:
13.32