SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ozx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 7 GLY A  72
ASP A 144
SER A  69
ALA A 294
 None
 1.00A 1gxsA-4ozxA:
undetectable
1gxsB-4ozxA:
undetectable		 1gxsA-4ozxA:
22.68
1gxsB-4ozxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 156
TYR A 174
ILE A 159
TYR A 280
THR A  90
 None
 1.04A 1p91B-4ozxA:
undetectable		 1p91B-4ozxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 5 PHE A 296
LEU A 137
PHE A  76
SER A  35
 None
 1.21A 1wrlC-4ozxA:
undetectable		 1wrlC-4ozxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		5 / 10 THR A 147
ASN A 152
TRP A 153
VAL A 151
GLY A 150
 None
 1.41A 2x2iD-4ozxA:
undetectable		 2x2iD-4ozxA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A 164
ILE A 159
TYR A 280
ARG A  93
 None
 1.25A 3ccfB-4ozxA:
undetectable		 3ccfB-4ozxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A 202
GLN A 282
GLU A  95
GLU A 169
 None
 1.09A 3dh0A-4ozxA:
undetectable		 3dh0A-4ozxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 6 ASP A 289
TYR A 291
ASP A 290
LYS A 287
 None
 1.50A 3pocB-4ozxA:
undetectable		 3pocB-4ozxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A  60
ASN A  62
ASP A  64
VAL A  40
 None
 1.02A 4f8hB-4ozxA:
undetectable
4f8hC-4ozxA:
undetectable		 4f8hB-4ozxA:
24.61
4f8hC-4ozxA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A  60
ASN A  62
ASP A  64
VAL A  40
 None
 1.08A 4f8hC-4ozxA:
undetectable
4f8hD-4ozxA:
undetectable		 4f8hC-4ozxA:
24.61
4f8hD-4ozxA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A  60
ASN A  62
ASP A  64
VAL A  40
 None
 1.08A 4f8hD-4ozxA:
undetectable
4f8hE-4ozxA:
undetectable		 4f8hD-4ozxA:
24.61
4f8hE-4ozxA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 8 VAL A  40
TYR A  60
ASN A  62
ASP A  64
 None
 1.06A 4f8hA-4ozxA:
undetectable
4f8hE-4ozxA:
undetectable		 4f8hA-4ozxA:
24.61
4f8hE-4ozxA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		4 / 5 TYR A 280
ILE A 160
PRO A  39
THR A 147
 None
 1.29A 4ze1A-4ozxA:
undetectable		 4ze1A-4ozxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 100
GLY A 131
GLY A 132
VAL A 118
ARG A  97
 None
 1.08A 5uc1A-4ozxA:
undetectable		 5uc1A-4ozxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4ozx ALGINATE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 100
GLY A 131
GLY A 132
VAL A 118
ARG A  97
 None
 1.09A 5uc1B-4ozxA:
undetectable		 5uc1B-4ozxA:
17.45