SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 8 GLN A 125
LEU A 247
ARG A 243
LEU A 134
 None
 1.12A 1hk3A-4p08A:
undetectable		 1hk3A-4p08A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 7 HIS A 558
ARG A 556
TYR A 391
LEU A 428
 None
 1.09A 1ibgL-4p08A:
undetectable		 1ibgL-4p08A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU4_A_BEZA584_0
(COCAINE ESTERASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		10 / 10 TYR A  44
SER A 117
TYR A 118
PRO A 150
TRP A 151
TRP A 166
PHE A 261
HIS A 287
LEU A 407
PHE A 408
 None
 0.29A 1ju4A-4p08A:
64.6		 1ju4A-4p08A:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		8 / 10 TYR A  44
TYR A 118
PRO A 150
TRP A 151
TRP A 166
HIS A 287
LEU A 407
PHE A 408
 None
 0.58A 1l7qA-4p08A:
64.8		 1l7qA-4p08A:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		8 / 10 TYR A  44
TYR A 118
PRO A 150
TRP A 151
TRP A 166
PHE A 261
LEU A 407
PHE A 408
 None
 0.18A 1l7qA-4p08A:
64.8		 1l7qA-4p08A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 8 ASP A  73
GLY A  76
THR A 176
ASP A  45
 None
 0.87A 1m4iA-4p08A:
undetectable		 1m4iA-4p08A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 9 ASP A  73
GLY A  76
SER A 177
SER A 179
ASP A  45
 None
 1.20A 1m4iB-4p08A:
0.0		 1m4iB-4p08A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 THR A  74
PRO A  86
TYR A 118
 None
 0.86A 2dxrA-4p08A:
undetectable		 2dxrA-4p08A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 PHE A 114
GLY A 112
ASN A 110
VAL A  63
TYR A  67
 None
 1.43A 2nyrB-4p08A:
undetectable		 2nyrB-4p08A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 ALA A  92
ASP A  93
GLU A  91
ARG A 243
 None
 1.46A 2ouzA-4p08A:
undetectable		 2ouzA-4p08A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 GLY A 411
ASP A 412
SER A 286
 None
 0.54A 2qhfA-4p08A:
undetectable		 2qhfA-4p08A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 GLY A 120
PHE A 261
SER A 143
HIS A 287
ARG A  41
 None
 1.04A 3dlcA-4p08A:
undetectable		 3dlcA-4p08A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_1
(16S RRNA METHYLASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 4 ASN A 294
ASP A 343
GLU A 440
TRP A 285
 None
 1.36A 3mteA-4p08A:
0.0		 3mteA-4p08A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 8 ALA A 357
ASP A 355
GLY A 443
VAL A 439
 None
 0.74A 3nu9A-4p08A:
undetectable		 3nu9A-4p08A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 TYR A 430
ASP A 425
ASP A 389
 None
 0.69A 3r24A-4p08A:
undetectable		 3r24A-4p08A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 LEU A 378
ALA A 369
ASP A 389
LEU A 428
 None
 1.01A 3rozA-4p08A:
undetectable		 3rozA-4p08A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 GLY A 109
VAL A 111
PRO A  36
TYR A  67
 None
 0.88A 4dxuA-4p08A:
undetectable		 4dxuA-4p08A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 8 GLN A 523
ILE A 421
GLY A 404
ASN A 413
 None
 1.02A 4fgjA-4p08A:
2.2
4fgjB-4p08A:
2.2		 4fgjA-4p08A:
18.55
4fgjB-4p08A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 7 THR A 442
ARG A 346
TRP A 351
TRP A 257
 None
 1.46A 4nsbA-4p08A:
undetectable		 4nsbA-4p08A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 7 PHE A  84
ILE A 170
PHE A  78
ASN A  42
 None
 1.19A 4o7gA-4p08A:
undetectable
4o7gB-4p08A:
undetectable		 4o7gA-4p08A:
18.98
4o7gB-4p08A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 PHE A  84
ILE A 170
PHE A  78
ASN A  42
 None
 1.21A 4o7gB-4p08A:
undetectable		 4o7gB-4p08A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 PHE A 468
ILE A 474
TYR A 258
PHE A 299
 None
 1.46A 4o7gB-4p08A:
undetectable		 4o7gB-4p08A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 ALA A 473
ILE A 567
LEU A 569
PRO A 570
ILE A 520
 None
 1.02A 4p3qA-4p08A:
undetectable		 4p3qA-4p08A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 VAL A 199
SER A 401
GLN A 211
LEU A 208
LEU A 158
 None
 1.46A 4qztA-4p08A:
undetectable		 4qztA-4p08A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 VAL A 111
GLN A 104
CYH A 107
 None
 0.76A 5icxA-4p08A:
undetectable
5icxE-4p08A:
undetectable		 5icxA-4p08A:
17.38
5icxE-4p08A:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 VAL A 111
GLN A 104
CYH A 107
 None
 0.91A 5icxC-4p08A:
undetectable
5icxF-4p08A:
undetectable		 5icxC-4p08A:
17.38
5icxF-4p08A:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 THR A 349
PRO A 354
ASP A 355
 None
 0.90A 5l8dB-4p08A:
undetectable		 5l8dB-4p08A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 THR A 349
PRO A 354
ASP A 355
 None
 0.90A 5mwuB-4p08A:
undetectable		 5mwuB-4p08A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 6 PHE A 514
LEU A 515
ARG A 519
GLY A 517
 None
 1.10A 5o4yF-4p08A:
undetectable		 5o4yF-4p08A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 VAL A 205
LEU A 164
VAL A 199
GLY A 201
PHE A 529
 None
 1.18A 6a94B-4p08A:
2.2		 6a94B-4p08A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 7 PHE A 317
ARG A 320
ALA A 138
GLN A 123
 None
 1.25A 6b89A-4p08A:
undetectable		 6b89A-4p08A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		4 / 4 HIS A 314
VAL A 281
LEU A 252
ALA A 310
 None
 1.27A 6d8pB-4p08A:
4.9		 6d8pB-4p08A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 THR A 510
THR A 442
ASP A 343
HIS A 518
LEU A 476
 None
 1.40A 6exiA-4p08A:
3.6		 6exiA-4p08A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		3 / 3 VAL A 465
ALA A 473
GLN A 523
 None
 0.69A 6gb9A-4p08A:
3.6		 6gb9A-4p08A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4p08 COCAINE ESTERASE
(Rhodococcus
sp.
MB1) 		5 / 12 TRP A 220
LEU A 163
LEU A 217
GLY A 215
ALA A 168
 None
 1.29A 6r2eH-4p08A:
undetectable		 6r2eH-4p08A:
20.36