SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		5 / 10 ASP A 110
PHE A 105
TYR A  82
GLY A 114
ARG A 116
 None
 0.92A 1rmtA-4p0aA:
undetectable		 1rmtA-4p0aA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		5 / 10 ASP A 110
PHE A 105
TYR A  82
GLY A 114
ARG A 116
 None
 0.92A 2b8jB-4p0aA:
undetectable		 2b8jB-4p0aA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		5 / 10 LEU A  51
LEU A  56
LEU A  72
LEU A 156
ARG A 157
 None
 1.10A 2xn6A-4p0aA:
undetectable
2xn6B-4p0aA:
undetectable		 2xn6A-4p0aA:
21.76
2xn6B-4p0aA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 5 ARG A 116
LEU A 119
VAL A  98
ASP A 110
 None
 1.17A 3ufnA-4p0aA:
undetectable
3ufnB-4p0aA:
undetectable		 3ufnA-4p0aA:
19.13
3ufnB-4p0aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 8 LEU A  79
VAL A 153
VAL A 149
GLN A 145
 None
 0.88A 4em2A-4p0aA:
0.9		 4em2A-4p0aA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 5 LEU A 155
GLU A  80
LEU A  31
HIS A 168
 None
 0.80A 4xi3B-4p0aA:
undetectable		 4xi3B-4p0aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 8 HIS A 144
LEU A 151
THR A 148
ALA A 147
 None
 0.88A 5tt3H-4p0aA:
undetectable		 5tt3H-4p0aA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 7 VAL A 149
LEU A  56
GLY A 123
GLY A 115
 None
 0.78A 6eu9D-4p0aA:
undetectable		 6eu9D-4p0aA:
19.30