SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		3 / 3 ALA A 428
VAL A 426
TRP A 425
 None
 0.92A 1bdwA-4p0dA:
undetectable
1bdwB-4p0dA:
undetectable		 1bdwA-4p0dA:
2.35
1bdwB-4p0dA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		3 / 3 ALA A 423
VAL A 426
TRP A 425
 None
 0.91A 1c4dA-4p0dA:
undetectable
1c4dB-4p0dA:
undetectable		 1c4dA-4p0dA:
2.35
1c4dB-4p0dA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ILE A  97
ASN A  98
ASN A 318
THR A 132
 None
 1.17A 1h7xA-4p0dA:
undetectable		 1h7xA-4p0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ILE A  97
ASN A  98
ASN A 318
THR A 132
 None
 1.14A 1h7xB-4p0dA:
undetectable		 1h7xB-4p0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ILE A  97
ASN A  98
ASN A 318
THR A 132
 None
 1.15A 1h7xC-4p0dA:
undetectable		 1h7xC-4p0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ILE A  97
ASN A  98
ASN A 318
THR A 132
 None
 1.14A 1h7xD-4p0dA:
undetectable		 1h7xD-4p0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		5 / 12 PHE A  72
LEU A 167
ALA A 124
GLY A 169
LEU A  80
 None
 1.26A 1kglA-4p0dA:
undetectable		 1kglA-4p0dA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 7 GLY A 337
PRO A 332
ASN A 323
ASN A 220
 None
 0.78A 1oniG-4p0dA:
undetectable
1oniI-4p0dA:
undetectable		 1oniG-4p0dA:
15.98
1oniI-4p0dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ILE A 480
PHE A 463
ILE A 380
ASP A 381
 None
 0.97A 1yc2E-4p0dA:
undetectable		 1yc2E-4p0dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 4 LEU A 233
SER A 239
ASP A 227
ASP A 343
 None
 1.29A 2br4B-4p0dA:
undetectable		 2br4B-4p0dA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ILE A 480
SER A 452
ILE A 466
PHE A 463
 None
 1.08A 2q72A-4p0dA:
undetectable		 2q72A-4p0dA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 8 TYR A 119
TYR A 140
THR A 132
THR A 215
 None
None
None
IOD  A 601 (-3.5A)
 1.03A 2v0zO-4p0dA:
undetectable		 2v0zO-4p0dA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ALA A 408
ALA A 368
THR A 385
PHE A 354
 None
 0.90A 2xfhA-4p0dA:
undetectable		 2xfhA-4p0dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 7 GLY A 371
VAL A 383
ASP A 381
ILE A 380
 None
 0.92A 3fi0P-4p0dA:
undetectable		 3fi0P-4p0dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 4 SER A 493
SER A 499
THR A 429
SER A 495
 None
 0.97A 3loqA-4p0dA:
undetectable		 3loqA-4p0dA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		5 / 12 GLY A 123
GLY A  60
VAL A 126
ALA A  39
LEU A 167
 None
 1.06A 3p2kB-4p0dA:
undetectable		 3p2kB-4p0dA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		5 / 12 GLY A 123
GLY A  60
VAL A 126
ALA A  39
LEU A 167
 None
 1.09A 3p2kC-4p0dA:
undetectable		 3p2kC-4p0dA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		5 / 12 THR A 157
GLY A  60
ALA A 124
ALA A 147
LEU A 167
 None
 1.15A 3p5nA-4p0dA:
undetectable		 3p5nA-4p0dA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		5 / 12 THR A 157
GLY A  60
ALA A 124
ALA A 147
LEU A 167
 None
 1.16A 3p5nB-4p0dA:
undetectable		 3p5nB-4p0dA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 6 THR A 320
ASN A  95
GLY A  96
ILE A  57
 None
 0.96A 3w9tF-4p0dA:
undetectable		 3w9tF-4p0dA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ILE A 380
THR A 394
SER A 198
PHE A 463
 None
 1.35A 4iarA-4p0dA:
undetectable		 4iarA-4p0dA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 4 SER A 239
ASP A 227
MET A 229
ASP A 343
 None
 1.44A 4iv0A-4p0dA:
undetectable		 4iv0A-4p0dA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 7 LEU A 199
THR A 439
ILE A 480
GLY A 456
 None
 0.96A 4l39B-4p0dA:
undetectable		 4l39B-4p0dA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 4 SER A 239
ASP A 227
MET A 229
ASP A 343
 None
 1.43A 4mwzB-4p0dA:
undetectable		 4mwzB-4p0dA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN
(Streptococcus
pyogenes) 		4 / 5 THR A  53
THR A 107
THR A  99
ASN A 318
 None
 1.33A 4pgfB-4p0dA:
undetectable		 4pgfB-4p0dA:
21.83