SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 PHE A 285
LEU A 281
VAL A 279
VAL A  20
ALA A 319
 None
 1.20A 1q23H-4p0fA:
undetectable
1q23I-4p0fA:
undetectable		 1q23H-4p0fA:
18.39
1q23I-4p0fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 PHE A  16
ALA A  47
ALA A  45
LEU A 369
MET A 336
 None
 1.13A 1qabF-4p0fA:
undetectable		 1qabF-4p0fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 PHE A  77
VAL A  20
LEU A 281
LEU A  65
LEU A 288
 None
 1.32A 1ya4B-4p0fA:
undetectable		 1ya4B-4p0fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 LEU A 270
GLU A 326
GLY A 327
ASN A 324
ALA A 330
 None
 1.12A 2bm9C-4p0fA:
undetectable		 2bm9C-4p0fA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 LEU A 270
GLU A 326
GLY A 327
ASN A 324
ALA A 330
 None
 0.92A 2bm9E-4p0fA:
undetectable		 2bm9E-4p0fA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 LEU A  13
ALA A  44
MET A 290
LEU A 281
LEU A 288
 None
 1.28A 2oaxB-4p0fA:
undetectable		 2oaxB-4p0fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 11 PHE A 359
SER A  36
LEU A 229
ILE A 168
PHE A 170
 None
 1.41A 2v0mA-4p0fA:
undetectable		 2v0mA-4p0fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 11 SER A  36
LEU A 229
ILE A 168
PHE A 170
ALA A 330
 None
 1.41A 2v0mA-4p0fA:
undetectable		 2v0mA-4p0fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 4 ILE A 168
PHE A  38
ILE A  92
THR A 334
 None
 1.06A 3ia4A-4p0fA:
undetectable		 3ia4A-4p0fA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 7 MET A 231
LEU A 220
PHE A 359
VAL A 376
 None
 1.16A 3jwqC-4p0fA:
undetectable		 3jwqC-4p0fA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		3 / 3 ASP A 368
ARG A  11
ALA A  14
 None
 0.80A 3mbgC-4p0fA:
undetectable		 3mbgC-4p0fA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 5 PHE A 372
ILE A  33
ASN A 144
PHE A  35
 None
 1.09A 3octA-4p0fA:
undetectable		 3octA-4p0fA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 8 PHE A 178
GLU A 322
LEU A 270
PHE A 273
 None
 0.99A 3rqwC-4p0fA:
undetectable
3rqwD-4p0fA:
undetectable		 3rqwC-4p0fA:
22.70
3rqwD-4p0fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 8 GLU A 322
LEU A 270
PHE A 273
PHE A 178
 None
 0.99A 3rqwF-4p0fA:
undetectable
3rqwJ-4p0fA:
undetectable		 3rqwF-4p0fA:
22.70
3rqwJ-4p0fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 8 VAL A  20
VAL A 284
ILE A 315
PHE A 285
 None
 0.78A 3warA-4p0fA:
undetectable		 3warA-4p0fA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 6 GLY A  64
PHE A  77
ILE A  73
PHE A 116
 None
 0.94A 4qogA-4p0fA:
undetectable
4qogB-4p0fA:
undetectable		 4qogA-4p0fA:
23.21
4qogB-4p0fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 4 GLY A 374
LEU A 281
PHE A 285
ILE A  40
 None
 0.91A 4xv2A-4p0fA:
undetectable		 4xv2A-4p0fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 11 VAL A 338
PHE A 108
LEU A 104
GLY A  50
ARG A 161
 None
 1.35A 4zbqA-4p0fA:
undetectable		 4zbqA-4p0fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 LEU A  13
PHE A  16
LEU A 281
LEU A  24
ALA A 332
 None
 1.11A 5ieoA-4p0fA:
undetectable		 5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 12 LEU A 112
PHE A 116
LEU A  65
LEU A  63
ALA A  51
 None
 1.39A 5ieoA-4p0fA:
undetectable		 5ieoA-4p0fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 8 ILE A 316
VAL A 165
ALA A 131
THR A 134
 None
 0.77A 5og9A-4p0fA:
undetectable		 5og9A-4p0fA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 8 GLN A  41
GLY A  64
GLU A   8
ILE A  73
 None
 0.94A 5vlmD-4p0fA:
undetectable		 5vlmD-4p0fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		5 / 9 LEU A  24
VAL A  20
VAL A 284
ILE A 315
PHE A 285
 None
 0.94A 5yf9X-4p0fA:
undetectable		 5yf9X-4p0fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		4 / 7 VAL A  20
VAL A 284
ILE A 315
PHE A 285
 None
 0.79A 5ywmX-4p0fA:
undetectable		 5ywmX-4p0fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B
(Drosophila
melanogaster) 		3 / 3 TRP A 174
GLU A 325
GLU A 322
 None
 0.92A 6fhwA-4p0fA:
undetectable		 6fhwA-4p0fA:
11.69