SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JJP_A_KLNA413_1 (CYTOCHROME P450 113A1)	4p0r	CROSSOVER JUNCTION ENDONUCLEASE EME1 (Homo sapiens)	5 / 12	ALA B 421 LEU B 359 ALA B 358 THR B 311 PHE B 439	None	1.23A	2jjpA-4p0rB: undetectable	2jjpA-4p0rB: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V3K_A_SAMA1254_0 (ESSENTIAL FOR MITOTIC GROWTH 1)	4p0r	CROSSOVER JUNCTION ENDONUCLEASE EME1 (Homo sapiens)	5 / 10	LEU B 269 GLY B 271 LEU B 432 SER B 428 ALA B 433	None	0.85A	2v3kA-4p0rB: undetectable	2v3kA-4p0rB: 19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_B_SALB1305_1 (LYSR-TYPE REGULATORY PROTEIN)	4p0r	CROSSOVER JUNCTION ENDONUCLEASE EME1 (Homo sapiens)	4 / 5	SER B 542 ARG B 544 PRO B 547 GLY B 546	None	1.25A	2y7kB-4p0rB: undetectable	2y7kB-4p0rB: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7P_A_SALA1001_1 (LYSR-TYPE REGULATORY PROTEIN)	4p0r	CROSSOVER JUNCTION ENDONUCLEASE EME1 (Homo sapiens)	4 / 6	SER B 542 ARG B 544 PRO B 547 GLY B 546	None	1.48A	2y7pA-4p0rB: undetectable	2y7pA-4p0rB: 20.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JJP_A_KLNA413_1","CYTOCHROME P450 113A1","4p0r","CROSSOVER JUNCTION ENDONUCLEASE EME1","Homo sapiens",5,"ALA B 421;LEU B 359;ALA B 358;THR B 311;PHE B 439","None","1.23A","2jjpA-4p0rB:undetectable","2jjpA-4p0rB:22.74"],["2V3K_A_SAMA1254_0","ESSENTIAL FOR MITOTIC GROWTH 1","4p0r","CROSSOVER JUNCTION ENDONUCLEASE EME1","Homo sapiens",5,"LEU B 269;GLY B 271;LEU B 432;SER B 428;ALA B 433","None","0.85A","2v3kA-4p0rB:undetectable","2v3kA-4p0rB:19.85"],["2Y7K_B_SALB1305_1","LYSR-TYPE REGULATORY PROTEIN","4p0r","CROSSOVER JUNCTION ENDONUCLEASE EME1","Homo sapiens",4,"SER B 542;ARG B 544;PRO B 547;GLY B 546","None","1.25A","2y7kB-4p0rB:undetectable","2y7kB-4p0rB:20.41"],["2Y7P_A_SALA1001_1","LYSR-TYPE REGULATORY PROTEIN","4p0r","CROSSOVER JUNCTION ENDONUCLEASE EME1","Homo sapiens",4,"SER B 542;ARG B 544;PRO B 547;GLY B 546","None","1.48A","2y7pA-4p0rB:undetectable","2y7pA-4p0rB:20.41"]]