SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
3 / 3 ARG A 401
THR A 391
VAL A 388
None
0.75A 1hxbA-4p0sA:
undetectable
1hxbA-4p0sA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
3 / 3 ARG A 401
THR A 391
VAL A 388
None
0.66A 2q64A-4p0sA:
undetectable
2q64A-4p0sA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
3 / 3 ARG A 401
THR A 391
VAL A 388
None
0.70A 2qakA-4p0sA:
undetectable
2qakA-4p0sA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
4 / 5 GLN A 420
THR A 416
ARG A 417
ALA A 413
None
1.40A 2qhfA-4p0sA:
undetectable
2qhfA-4p0sA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
4 / 4 TYR A 507
GLY A 533
SER A 521
LEU A 520
None
1.41A 5bphC-4p0sA:
undetectable
5bphC-4p0sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
4 / 6 VAL A 327
LEU A 361
CYH A 272
LEU A 303
None
1.09A 5hrqB-4p0sA:
undetectable
5hrqI-4p0sA:
undetectable
5hrqJ-4p0sA:
undetectable
5hrqB-4p0sA:
7.19
5hrqI-4p0sA:
5.46
5hrqJ-4p0sA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
3 / 3 LEU A 453
LEU A 454
TRP A 433
None
0.68A 5nwuA-4p0sA:
undetectable
5nwuA-4p0sA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo
sapiens)
6 / 12 ASP A 404
GLU A 369
PHE A 308
LEU A 271
GLN A 292
LEU A 287
None
1.34A 6ew0G-4p0sA:
undetectable
6ew0G-4p0sA:
15.00