SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A  49
LEU A  28
LEU A 142
ILE A 139
ALA A 137
 None
 0.96A 1ha2A-4p0vA:
undetectable		 1ha2A-4p0vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A 152
TYR A 146
LEU A 142
LEU A 156
 None
 0.99A 1i7zA-4p0vA:
undetectable		 1i7zA-4p0vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A 193
ASP A 244
ASP A 261
LEU A 173
 None
None
MG  A 404 ( 3.7A)
None
 1.03A 1pk2A-4p0vA:
undetectable		 1pk2A-4p0vA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.33A 1rqjA-4p0vA:
31.1		 1rqjA-4p0vA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.34A 1rqjB-4p0vA:
31.2		 1rqjB-4p0vA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 7 MET A 106
ASP A 107
ASP A 104
LYS A 257
 None
MG  A 405 (-2.4A)
None
1WO  A 402 ( 2.8A)
 1.22A 1t03A-4p0vA:
undetectable		 1t03A-4p0vA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 208
GLY A  61
GLY A  89
LEU A 142
ARG A  84
 None
 1.00A 1y4lA-4p0vA:
undetectable		 1y4lA-4p0vA:
14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.30A 1yhlA-4p0vA:
45.8		 1yhlA-4p0vA:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.34A 1yq7A-4p0vA:
53.1		 1yq7A-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 10 ASP A 107
ARG A 112
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 1.20A 1yv5A-4p0vA:
53.5		 1yv5A-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.18A 1yv5A-4p0vA:
53.5		 1yv5A-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.27A 1zw5A-4p0vA:
54.8		 1zw5A-4p0vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 0.41A 2e91A-4p0vA:
25.3		 2e91A-4p0vA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 0.56A 2e91B-4p0vA:
24.4		 2e91B-4p0vA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.27A 2f89F-4p0vA:
56.6		 2f89F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.13A 2f8cF-4p0vA:
56.3		 2f8cF-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 10 ASP A 107
ARG A 112
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 1.16A 2f8zF-4p0vA:
56.6		 2f8zF-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.29A 2f8zF-4p0vA:
56.6		 2f8zF-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.56A 2f94F-4p0vA:
55.2		 2f94F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.27A 2f94F-4p0vA:
55.2		 2f94F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.18A 2f9kF-4p0vA:
55.3		 2f9kF-4p0vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		8 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
 0.40A 2o1oA-4p0vA:
36.3		 2o1oA-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		8 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
 0.43A 2o1oB-4p0vA:
37.0		 2o1oB-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 10 LEU A 100
ASP A 103
ASP A 107
GLN A 171
LYS A 200
LYS A 266
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
MG  A 405 ( 4.4A)
 1.20A 2o1oB-4p0vA:
37.0		 2o1oB-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 10 LEU A 100
ASP A 103
ARG A 112
GLN A 171
LYS A 200
ASP A 261
 None
MG  A 405 (-2.5A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
MG  A 404 ( 3.7A)
 1.35A 2q58A-4p0vA:
36.2		 2q58A-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 244
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
None
 0.60A 2q58A-4p0vA:
36.2		 2q58A-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
 0.42A 2q58B-4p0vA:
36.3		 2q58B-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 ASP A 103
ASP A 107
GLN A 171
LYS A 200
LYS A 266
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
MG  A 405 ( 4.4A)
 1.38A 2q58B-4p0vA:
36.3		 2q58B-4p0vA:
29.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.23A 2qisA-4p0vA:
54.7		 2qisA-4p0vA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A 210
ILE A 139
LEU A 232
PHE A 206
 None
 1.18A 3adsA-4p0vA:
undetectable		 3adsA-4p0vA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 207
LEU A 232
VAL A 340
LEU A  71
MET A 214
 None
 1.16A 3dzyD-4p0vA:
1.9		 3dzyD-4p0vA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.48A 3ez3A-4p0vA:
45.5		 3ez3A-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.32A 3ez3B-4p0vA:
44.7		 3ez3B-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.46A 3ez3C-4p0vA:
45.4		 3ez3C-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.30A 3ez3D-4p0vA:
44.3		 3ez3D-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.45A 3ibaA-4p0vA:
45.6		 3ibaA-4p0vA:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.48A 3ldwA-4p0vA:
45.4		 3ldwA-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.32A 3ldwB-4p0vA:
44.6		 3ldwB-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.45A 3ldwC-4p0vA:
45.3		 3ldwC-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.31A 3ldwD-4p0vA:
44.3		 3ldwD-4p0vA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.19A 3n45F-4p0vA:
54.9		 3n45F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.25A 3n46F-4p0vA:
54.3		 3n46F-4p0vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 VAL A 124
TYR A  51
ASN A  52
VAL A 101
 None
 0.95A 4a9kA-4p0vA:
undetectable		 4a9kA-4p0vA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.30A 4kfaA-4p0vA:
53.4		 4kfaA-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.21A 4kpdA-4p0vA:
55.9		 4kpdA-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.26A 4kpjA-4p0vA:
53.7		 4kpjA-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.31A 4kq5A-4p0vA:
54.2		 4kq5A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.22A 4kqsA-4p0vA:
54.8		 4kqsA-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.29A 4n9uA-4p0vA:
54.2		 4n9uA-4p0vA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.53A 4ng6A-4p0vA:
55.0		 4ng6A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.33A 4ng6A-4p0vA:
55.0		 4ng6A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.38A 4nkeA-4p0vA:
53.7		 4nkeA-4p0vA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.30A 4nkfA-4p0vA:
54.6		 4nkfA-4p0vA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.44A 4nuaA-4p0vA:
54.5		 4nuaA-4p0vA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		9 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.21A 4oguA-4p0vA:
54.2		 4oguA-4p0vA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		11 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.14A 4p0wA-4p0vA:
57.2		 4p0wA-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.21A 4q23A-4p0vA:
53.7		 4q23A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.26A 4rxdA-4p0vA:
44.9		 4rxdA-4p0vA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.25A 4rxdB-4p0vA:
45.3		 4rxdB-4p0vA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		10 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.26A 4rxdC-4p0vA:
45.2		 4rxdC-4p0vA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 8 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
 0.68A 4umjA-4p0vA:
23.8		 4umjA-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		7 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
 0.59A 4umjB-4p0vA:
23.8		 4umjB-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
 1.24A 4umjB-4p0vA:
23.8		 4umjB-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 104
ARG A 351
ARG A  60
 None
1WO  A 402 ( 4.6A)
1WO  A 402 (-2.6A)
 0.88A 4x5iA-4p0vA:
undetectable		 4x5iA-4p0vA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		12 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.23A 5cg5A-4p0vA:
53.8		 5cg5A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		12 / 12 PHE A  99
LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
 None
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.23A 5cg6A-4p0vA:
54.7		 5cg6A-4p0vA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 100
ASP A 103
ARG A 112
LYS A 200
LYS A 257
 None
MG  A 405 (-2.5A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
1WO  A 402 ( 2.8A)
 1.36A 5eroA-4p0vA:
27.5		 5eroA-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		7 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 0.62A 5eroA-4p0vA:
27.5		 5eroA-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 ASP A 103
ARG A 112
LYS A 200
ASP A 244
LYS A 257
 MG  A 405 (-2.5A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
None
1WO  A 402 ( 2.8A)
 1.30A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 0.53A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 ASP A 103
ASP A 107
LYS A 200
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 1.42A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 9 ASP A 107
ARG A 112
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 1.34A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		8 / 10 ASP A 103
ASP A 104
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.5A)
None
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 0.58A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		7 / 10 ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 244
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
None
1WO  A 402 ( 2.8A)
 0.98A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 10 ASP A 103
ASP A 107
LYS A 200
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 1.39A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 10 ASP A 107
ASP A 104
ARG A 112
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.4A)
None
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 1.37A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 301
VAL A 298
TYR A 290
GLN A 292
 None
 1.21A 5qggA-4p0vA:
undetectable		 5qggA-4p0vA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 301
VAL A 298
TYR A 290
GLN A 292
 None
 1.23A 5qgoA-4p0vA:
undetectable		 5qgoA-4p0vA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 301
VAL A 298
TYR A 290
GLN A 292
 None
 1.24A 5qgpA-4p0vA:
undetectable		 5qgpA-4p0vA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 301
VAL A 298
TYR A 290
GLN A 292
 None
 1.17A 5qgqA-4p0vA:
undetectable		 5qgqA-4p0vA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 301
VAL A 298
TYR A 290
GLN A 292
 None
 1.21A 5qhbA-4p0vA:
undetectable		 5qhbA-4p0vA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A  61
TYR A  58
LEU A 344
VAL A  66
 None
1WO  A 402 (-3.7A)
None
None
 0.96A 5x80A-4p0vA:
undetectable
5x80B-4p0vA:
undetectable		 5x80A-4p0vA:
18.60
5x80B-4p0vA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 7 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
 1.07A 6g31A-4p0vA:
26.2		 6g31A-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 6 ASP A 103
ASP A 107
ARG A 112
GLN A 171
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.73A 6g31B-4p0vA:
26.2		 6g31B-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
 1.21A 6g31C-4p0vA:
26.5		 6g31C-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.54A 6g31D-4p0vA:
25.4		 6g31D-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 100
ASP A 103
ASP A 107
ARG A 112
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
 0.36A 6g31E-4p0vA:
13.1		 6g31E-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 103
ASP A 107
ARG A 112
GLN A 171
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.69A 6g31F-4p0vA:
26.1		 6g31F-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		6 / 7 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
 0.60A 6g31G-4p0vA:
25.4		 6g31G-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 103
ASP A 107
GLN A 171
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.47A 6g31H-4p0vA:
25.0		 6g31H-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 103
ASP A 107
LYS A 200
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
 1.00A 6g31I-4p0vA:
25.3		 6g31I-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
 0.86A 6g31J-4p0vA:
26.4		 6g31J-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 6 LEU A 100
ASP A 103
ASP A 107
GLN A 171
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.50A 6g31J-4p0vA:
26.4		 6g31J-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 103
ASP A 107
ARG A 112
GLN A 171
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
 0.43A 6g31K-4p0vA:
24.5		 6g31K-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 6 ASP A 103
ASP A 107
ARG A 112
GLN A 171
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.87A 6g31L-4p0vA:
25.9		 6g31L-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 6 ASP A 103
ASP A 107
GLN A 171
GLN A 240
LYS A 266
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
MG  A 405 ( 4.4A)
 1.15A 6g31L-4p0vA:
25.9		 6g31L-4p0vA:
15.75