SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 194
GLY A 244
ALA A 248
PRO A 189
ALA A 193
 None
 1.07A 1sg9C-4p13A:
undetectable		 1sg9C-4p13A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PHE A  78
ARG A 256
ASN A 325
 None
 0.86A 1xzxX-4p13A:
undetectable		 1xzxX-4p13A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 371
ALA A 260
GLY A 262
SER A 311
PRO A 257
 None
 0.98A 2okcA-4p13A:
undetectable		 2okcA-4p13A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 371
ALA A 260
GLY A 262
SER A 311
PRO A 257
 None
 0.98A 2okcB-4p13A:
undetectable		 2okcB-4p13A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 375
GLN A  95
TYR A 133
ILE A 167
 FAD  A 401 (-4.9A)
None
FAD  A 401 (-3.6A)
FAD  A 401 (-4.3A)
 1.33A 2ph9A-4p13A:
undetectable
2ph9B-4p13A:
undetectable		 2ph9A-4p13A:
20.98
2ph9B-4p13A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  87
PHE A  30
ILE A  53
ALA A  97
GLU A  41
 None
 1.22A 2v0mC-4p13A:
undetectable		 2v0mC-4p13A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN A 382
ASP A 338
SER A 379
TYR A 375
 None
None
None
FAD  A 401 (-4.9A)
 1.27A 2xz5A-4p13A:
undetectable
2xz5C-4p13A:
undetectable		 2xz5A-4p13A:
17.89
2xz5C-4p13A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 PRO A  49
TYR A  42
GLY A  93
THR A  92
 None
 1.16A 3ib0A-4p13A:
undetectable		 3ib0A-4p13A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A  53
ALA A  56
ILE A  83
ALA A  80
GLY A 262
 None
 0.89A 3nxuA-4p13A:
undetectable		 3nxuA-4p13A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A  92
LEU A 365
GLY A 265
TYR A 372
GLY A 262
 None
 1.00A 5e3iA-4p13A:
undetectable		 5e3iA-4p13A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LYS A 211
THR A 168
TYR A 176
PRO A  49
 None
FAD  A 401 (-3.9A)
None
None
 0.96A 5x2sI-4p13A:
undetectable
5x2sJ-4p13A:
undetectable
5x2sK-4p13A:
undetectable		 5x2sI-4p13A:
18.72
5x2sJ-4p13A:
15.60
5x2sK-4p13A:
18.72