SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 121
VAL A 139
ILE A 107
MET A 157
 None
 1.07A 1opjB-4p17A:
undetectable		 1opjB-4p17A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		3 / 3 SER A 236
HIS A 113
ASP A 106
 None
 0.83A 2oxtA-4p17A:
undetectable		 2oxtA-4p17A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 11 MET A 157
LEU A 175
LEU A 232
SER A 234
VAL A 147
 None
 1.35A 2po5B-4p17A:
undetectable		 2po5B-4p17A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		4 / 4 GLN A  41
PRO A  38
VAL A  37
GLU A  34
 None
 1.21A 3huoA-4p17A:
undetectable		 3huoA-4p17A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 207
GLY A 204
GLN A 211
LEU A 199
ILE A 306
 None
 1.45A 4p6xA-4p17A:
undetectable		 4p6xA-4p17A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 10 VAL A  72
THR A  76
PHE A 250
TYR A  12
GLY A  63
 None
 1.17A 5mxbA-4p17A:
undetectable		 5mxbA-4p17A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4p17 RABGAP/TBC PROTEIN
(Chlamydomonas
reinhardtii) 		3 / 3 ARG A 259
HIS A 305
ARG A  61
 None
 1.08A 6dwdD-4p17A:
undetectable		 6dwdD-4p17A:
19.34