SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 9 LEU A 313
GLY A  93
VAL A 320
ILE A 235
ILE A 105
 None
 1.01A 1hpvA-4p1eA:
undetectable		 1hpvA-4p1eA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		4 / 8 PHE A  99
LEU A 140
ILE A 241
ILE A 242
 None
 0.87A 1sbrA-4p1eA:
undetectable		 1sbrA-4p1eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 PHE A 121
GLN A 133
LEU A 311
PRO A 308
VAL A 307
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.25A 2qd4A-4p1eA:
undetectable		 2qd4A-4p1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 PHE A 121
GLN A 133
LEU A 311
PRO A 308
VAL A 307
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.23A 2qd4B-4p1eA:
undetectable		 2qd4B-4p1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 143
VAL A  90
ILE A  42
GLY A  45
ILE A 241
 None
 1.04A 3mwsB-4p1eA:
undetectable		 3mwsB-4p1eA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 143
VAL A  90
ILE A  42
GLY A  45
ILE A 241
 None
 1.14A 3nu5B-4p1eA:
undetectable		 3nu5B-4p1eA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 248
LEU A  30
ASN A  31
ILE A 242
ILE A 241
 None
 1.13A 3ut5B-4p1eA:
undetectable		 3ut5B-4p1eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 248
LEU A  30
ASN A  31
ILE A 242
ILE A 241
 None
 1.11A 4o2bB-4p1eA:
undetectable		 4o2bB-4p1eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		4 / 6 PHE A 300
ASP A 165
LEU A 166
THR A 230
 None
 1.29A 4paeA-4p1eA:
undetectable		 4paeA-4p1eA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 7 GLY A 139
SER A 138
PHE A  99
VAL A 243
LEU A  78
 IOD  A 404 ( 4.1A)
IOD  A 411 ( 3.1A)
None
None
None
 1.41A 5izjB-4p1eA:
undetectable		 5izjB-4p1eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 7 GLY A 139
SER A 138
PHE A  99
VAL A 243
LEU A  78
 IOD  A 404 ( 4.1A)
IOD  A 411 ( 3.1A)
None
None
None
 1.42A 5izjA-4p1eA:
undetectable		 5izjA-4p1eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 9 LEU A 143
VAL A  90
ILE A  42
GLY A  45
ILE A 241
 None
 1.10A 5kqxB-4p1eA:
undetectable		 5kqxB-4p1eA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 154
PRO A 109
LEU A 311
PHE A 300
ILE A 183
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.09A 5ljeA-4p1eA:
undetectable		 5ljeA-4p1eA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		5 / 12 LEU A 248
LEU A  30
ASN A  31
ILE A 242
ILE A 241
 None
 1.06A 5mioB-4p1eA:
undetectable		 5mioB-4p1eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Escherichia
fergusonii) 		3 / 3 MET A 281
ASP A  40
ARG A 152
 None
 1.06A 5z6kA-4p1eA:
undetectable		 5z6kA-4p1eA:
20.00