SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		3 / 3 ASN A 298
PHE A 306
VAL A 165
 None
 0.86A 1kijA-4p1lA:
undetectable		 1kijA-4p1lA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 7 GLY A 103
MET A 179
ILE A 105
VAL A 106
 None
BDP  A 401 (-3.5A)
None
None
 0.98A 1rxcC-4p1lA:
undetectable		 1rxcC-4p1lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 7 GLU A 244
ARG A 276
GLU A 280
PRO A  47
 BDP  A 401 (-3.0A)
None
None
None
 1.37A 3ql6A-4p1lA:
undetectable		 3ql6A-4p1lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 6 TYR A  46
GLU A 244
LEU A  52
PHE A 151
 None
BDP  A 401 (-3.0A)
None
None
 1.29A 4twdD-4p1lA:
undetectable
4twdE-4p1lA:
undetectable		 4twdD-4p1lA:
23.29
4twdE-4p1lA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 7 GLU A 244
LEU A  52
PHE A 151
TYR A  46
 BDP  A 401 (-3.0A)
None
None
None
 1.18A 4twdF-4p1lA:
undetectable
4twdJ-4p1lA:
undetectable		 4twdF-4p1lA:
23.29
4twdJ-4p1lA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 6 TYR A  46
GLU A 244
LEU A  52
PHE A 151
 None
BDP  A 401 (-3.0A)
None
None
 1.18A 4twdF-4p1lA:
undetectable
4twdG-4p1lA:
undetectable		 4twdF-4p1lA:
23.29
4twdG-4p1lA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 6 TYR A  46
GLU A 244
LEU A  52
PHE A 151
 None
BDP  A 401 (-3.0A)
None
None
 1.11A 4twdI-4p1lA:
undetectable
4twdJ-4p1lA:
undetectable		 4twdI-4p1lA:
23.29
4twdJ-4p1lA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 7 VAL A 165
LEU A 158
SER A 157
GLU A 238
 None
 1.05A 4zphA-4p1lA:
undetectable
4zphB-4p1lA:
undetectable		 4zphA-4p1lA:
21.86
4zphB-4p1lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		3 / 3 ILE A 146
MET A 128
ASP A 138
 None
 0.85A 5h2uA-4p1lA:
undetectable		 5h2uA-4p1lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		5 / 12 ALA A 155
GLY A 154
SER A 153
GLU A 280
GLU A 274
 None
None
BDP  A 401 ( 4.9A)
None
None
 0.86A 5nwuA-4p1lA:
undetectable		 5nwuA-4p1lA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		4 / 5 TYR A 200
ASP A  79
PRO A  81
ALA A  75
 BDP  A 401 (-3.8A)
None
None
None
 1.01A 5otrA-4p1lA:
undetectable		 5otrA-4p1lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		3 / 3 CYH A 245
MET A  99
ASN A  98
 None
None
BDP  A 401 (-4.4A)
 0.86A 5qh8A-4p1lA:
undetectable		 5qh8A-4p1lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		3 / 3 MET A 102
GLU A  85
ARG A  88
 None
 1.12A 5tjyA-4p1lA:
undetectable		 5tjyA-4p1lA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		5 / 12 MET A 310
ALA A 305
GLU A 238
VAL A 165
TYR A 234
 None
 1.34A 5vlmH-4p1lA:
undetectable		 5vlmH-4p1lA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Chromohalobacter
salexigens) 		5 / 12 GLY A 154
TYR A 234
ARG A 156
GLU A 244
GLY A 152
 None
None
BDP  A 401 (-3.0A)
BDP  A 401 (-3.0A)
None
 1.41A 6gngA-4p1lA:
undetectable		 6gngA-4p1lA:
21.62