SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4p1n ATG1 TMIT
(Kluyveromyces
marxianus) 		5 / 11 LEU A 669
TYR A 670
GLU A 746
VAL A 745
ILE A 749
 None
 1.17A 1mrqA-4p1nA:
undetectable		 1mrqA-4p1nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4p1n ATG1 TMIT
(Kluyveromyces
marxianus) 		5 / 10 SER A 823
ARG A 827
ALA A 760
ALA A 761
GLU A 764
 None
 1.24A 1wygA-4p1nA:
2.4		 1wygA-4p1nA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4p1n ATG1 TMIT
(Kluyveromyces
marxianus) 		4 / 7 ILE A 654
PHE A 720
PHE A 593
LYS A 592
 None
 1.04A 3em0B-4p1nA:
undetectable		 3em0B-4p1nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4p1n ATG1 TMIT
(Kluyveromyces
marxianus) 		4 / 4 ASN A 570
SER A 679
LEU A 683
THR A 697
 None
 1.20A 4an2A-4p1nA:
undetectable		 4an2A-4p1nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4p1n ATG1 TMIT
(Kluyveromyces
marxianus) 		4 / 4 LEU A 748
PHE A 588
LEU A 662
GLU A 665
 None
 1.21A 4p7nA-4p1nA:
undetectable		 4p7nA-4p1nA:
21.09