SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ASN A1911
ALA A1914
ASN A1893
 None
 0.79A 1n4fA-4p1tA:
undetectable		 1n4fA-4p1tA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 4 THR A1269
GLN A1270
GLU A1518
ASP A1520
 None
 1.46A 1nw3A-4p1tA:
0.0		 1nw3A-4p1tA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 GLU A1456
TRP A1249
LYS A1422
 None
 1.22A 1qu2A-4p1tA:
undetectable		 1qu2A-4p1tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 GLU A1855
TRP A1802
LYS A1523
 None
 1.30A 1qu2A-4p1tA:
undetectable		 1qu2A-4p1tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 11 VAL A1708
ARG A1628
LEU A1633
ILE A1701
ASP A1706
 None
 1.34A 1t6zA-4p1tA:
undetectable		 1t6zA-4p1tA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 TYR A1867
ARG A1797
GLN A1794
 None
 1.01A 1tw4A-4p1tA:
undetectable		 1tw4A-4p1tA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 PHE A1551
TYR A1511
TYR A1508
TRP A1457
 None
 1.26A 2aoxA-4p1tA:
undetectable		 2aoxA-4p1tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 11 LEU A1310
ILE A1227
ALA A1303
GLU A1367
LEU A1272
 None
 1.35A 2v0mD-4p1tA:
undetectable		 2v0mD-4p1tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 5 GLN A1270
THR A1269
GLU A1307
HIS A1315
 None
 1.37A 3glqA-4p1tA:
undetectable		 3glqA-4p1tA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 5 GLN A1270
THR A1269
GLU A1307
HIS A1315
 None
 1.49A 3glqB-4p1tA:
undetectable		 3glqB-4p1tA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ARG A1797
ILE A1788
PHE A1695
 None
 0.73A 5kirA-4p1tA:
undetectable		 5kirA-4p1tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 GLU A1545
HIS A1345
PHE A1343
SER A1350
 None
 0.96A 5y2tB-4p1tA:
undetectable		 5y2tB-4p1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 TRP A1405
ILE A1300
GLU A1411
 None
 0.85A 6hcxA-4p1tA:
undetectable		 6hcxA-4p1tA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 THR A1234
GLU A1456
ASN A1271
 None
 0.74A 6nj9K-4p1tA:
undetectable		 6nj9K-4p1tA:
23.07