SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		3 / 3 ASP B 222
HIS B 216
ASP B  86
 None
 0.80A 1nw5A-4p1xB:
undetectable		 1nw5A-4p1xB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		3 / 3 ASN B 284
TRP B  25
GLN B  29
 None
 0.94A 1xoqA-4p1xB:
undetectable		 1xoqA-4p1xB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		3 / 3 ASP B  86
PHE B 226
SER B 151
 None
 0.95A 3i5uB-4p1xB:
undetectable		 3i5uB-4p1xB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		5 / 12 VAL B 280
PHE B  33
ILE B 228
LEU B  82
VAL B 214
 None
 1.09A 3w68B-4p1xB:
undetectable		 3w68B-4p1xB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		4 / 8 SER B 162
ASN B 141
GLY B 168
GLN B 169
 None
 0.99A 4af0A-4p1xB:
undetectable		 4af0A-4p1xB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4p1x GAMMA-HEMOLYSIN
COMPONENT C
(Staphylococcus
aureus) 		4 / 6 THR B 103
TYR B 137
THR B 138
SER B 136
 None
 1.33A 5b6iB-4p1xB:
undetectable		 5b6iB-4p1xB:
22.35