SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 7 VAL A 232
GLY A 230
THR A 280
ILE A 277
 None
 0.74A 1gtnC-4p22A:
undetectable
1gtnD-4p22A:
undetectable		 1gtnC-4p22A:
10.23
1gtnD-4p22A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 11 SER A 114
PHE A 116
LEU A 118
GLN A 115
ASP A 393
 None
 1.46A 2c2bE-4p22A:
undetectable
2c2bF-4p22A:
undetectable		 2c2bE-4p22A:
23.05
2c2bF-4p22A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 9 PHE A 195
GLY A 196
ASN A 398
ILE A 397
ALA A 428
 None
 1.38A 2drdA-4p22A:
3.6		 2drdA-4p22A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 LEU A  70
LEU A  62
MET A 410
 None
 0.79A 2itzA-4p22A:
undetectable		 2itzA-4p22A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMN_B_IPHB401_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 4 PRO A 326
HIS A 330
PRO A 313
TYR A 425
 None
 1.50A 2omnA-4p22A:
0.6
2omnB-4p22A:
0.0		 2omnA-4p22A:
18.61
2omnB-4p22A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 VAL A 248
THR A 274
ILE A 277
ASP A  51
PHE A 275
 None
 1.27A 2v95A-4p22A:
undetectable		 2v95A-4p22A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 LEU A 382
ARG A 325
ILE A 383
 None
 0.68A 2xn5B-4p22A:
undetectable		 2xn5B-4p22A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 8 LEU A 164
THR A 165
GLY A 402
ALA A 406
 None
 0.66A 3jusA-4p22A:
1.5		 3jusA-4p22A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 8 LEU A 164
THR A 165
GLY A 402
ALA A 406
 None
 0.66A 3jusA-4p22A:
1.5		 3jusA-4p22A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ALA A 189
VAL A 188
GLN A 172
 None
 0.53A 3of4B-4p22A:
undetectable		 3of4B-4p22A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ALA A 428
PHE A 426
ASP A 379
ASP A 427
PHE A 323
 None
 1.43A 3wemA-4p22A:
undetectable		 3wemA-4p22A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 5 PHE A 275
ILE A 277
GLY A 230
THR A 225
 None
 0.90A 4ejjC-4p22A:
undetectable		 4ejjC-4p22A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ARG A 239
HIS A 240
TYR A 273
 None
 1.16A 4fu8A-4p22A:
undetectable		 4fu8A-4p22A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ARG A 239
HIS A 240
TYR A 273
 None
 1.20A 4fu9A-4p22A:
undetectable		 4fu9A-4p22A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A  85
ALA A 412
LEU A  93
VAL A  99
 None
 1.08A 4ib4A-4p22A:
undetectable		 4ib4A-4p22A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 8 GLY A 105
THR A 148
LEU A 101
ASN A 126
 None
 1.14A 4m5mA-4p22A:
undetectable		 4m5mA-4p22A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A  85
ALA A 412
LEU A  93
VAL A  99
 None
 1.09A 4nc3A-4p22A:
undetectable		 4nc3A-4p22A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		6 / 12 ASP A 393
ILE A 397
ILE A  87
ARG A  81
VAL A  77
ILE A  91
 None
 1.29A 4q5mA-4p22A:
undetectable		 4q5mA-4p22A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ASP A 279
LEU A  54
GLY A  53
 None
 0.57A 4xmfA-4p22A:
undetectable		 4xmfA-4p22A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ARG A 127
ASN A 166
ASP A 171
 None
 0.92A 5gwxA-4p22A:
undetectable		 5gwxA-4p22A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 4 LEU A 135
LEU A  80
GLY A  84
GLU A  86
 None
 1.13A 5hhjA-4p22A:
undetectable		 5hhjA-4p22A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ALA A 405
GLY A  79
GLY A  84
ARG A  81
VAL A 163
 None
 1.10A 6clxA-4p22A:
5.2		 6clxA-4p22A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0B-4p22A:
undetectable		 6ew0B-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0D-4p22A:
undetectable		 6ew0D-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0F-4p22A:
undetectable		 6ew0F-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0G-4p22A:
undetectable		 6ew0G-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0H-4p22A:
undetectable		 6ew0H-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0I-4p22A:
undetectable		 6ew0I-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens) 		4 / 8 HIS A 102
ARG A 174
ASP A 171
GLU A 170
 None
 1.08A 6mn4D-4p22A:
undetectable		 6mn4D-4p22A:
21.15