SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_A_HSMA1160_1 (ALLERGEN ARG R 1)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 6	TYR A 81 TYR A 58 ASP A 90 TRP A 91	None	1.25A	2x45A-4p27A: undetectable	2x45A-4p27A: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_B_HSMB1160_1 (ALLERGEN ARG R 1)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 7	TYR A 81 TYR A 58 ASP A 90 TRP A 91	None	1.26A	2x45B-4p27A: undetectable	2x45B-4p27A: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BU1_A_HSMA301_1 (LIPOCALIN)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 7	TYR A 81 TYR A 58 ASP A 90 TRP A 91	None	1.25A	3bu1A-4p27A: undetectable	3bu1A-4p27A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_A_5FWA1002_1 (SUPEROXIDE DISMUTASE [CU-ZN])	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	3 / 3	ASN A 111 TRP A 91 ASP A 144	None	1.27A	4a7tA-4p27A: undetectable 4a7tF-4p27A: undetectable	4a7tA-4p27A: 19.89 4a7tF-4p27A: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 7	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	1.05A	4a97E-4p27A: undetectable	4a97E-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 8	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	1.06A	4a97C-4p27A: undetectable	4a97C-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 8	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	0.92A	4a97D-4p27A: undetectable	4a97D-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 8	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	1.00A	4a97G-4p27A: undetectable	4a97G-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_I_ZPCI1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 7	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	0.96A	4a97H-4p27A: undetectable	4a97H-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 8	PHE A 14 VAL A 18 ILE A 27 GLU A 85	None	1.00A	4a97I-4p27A: undetectable	4a97I-4p27A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1431_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	4p27	VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN (Schistosoma mansoni)	4 / 5	HIS A 15 ASP A 144 GLY A 75 ASN A 77	None	1.43A	5x7pB-4p27A: undetectable	5x7pB-4p27A: 7.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X45_A_HSMA1160_1","ALLERGEN ARG R 1","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"TYR A  81;TYR A  58;ASP A  90;TRP A  91","None","1.25A","2x45A-4p27A:undetectable","2x45A-4p27A:17.37"],["2X45_B_HSMB1160_1","ALLERGEN ARG R 1","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"TYR A  81;TYR A  58;ASP A  90;TRP A  91","None","1.26A","2x45B-4p27A:undetectable","2x45B-4p27A:17.37"],["3BU1_A_HSMA301_1","LIPOCALIN","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"TYR A  81;TYR A  58;ASP A  90;TRP A  91","None","1.25A","3bu1A-4p27A:undetectable","3bu1A-4p27A:19.57"],["4A7T_A_5FWA1002_1","SUPEROXIDE DISMUTASE [CU-ZN];SUPEROXIDE DISMUTASE [CU-ZN]","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",3,"ASN A 111;TRP A  91;ASP A 144","None","1.27A","4a7tA-4p27A:undetectable;4a7tF-4p27A:undetectable","4a7tA-4p27A:19.89;4a7tF-4p27A:19.89"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","1.05A","4a97E-4p27A:undetectable","4a97E-4p27A:18.57"],["4A97_D_ZPCD1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","1.06A","4a97C-4p27A:undetectable","4a97C-4p27A:18.57"],["4A97_E_ZPCE1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","0.92A","4a97D-4p27A:undetectable","4a97D-4p27A:18.57"],["4A97_H_ZPCH1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","1.00A","4a97G-4p27A:undetectable","4a97G-4p27A:18.57"],["4A97_I_ZPCI1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","0.96A","4a97H-4p27A:undetectable","4a97H-4p27A:18.57"],["4A97_J_ZPCJ1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"PHE A  14;VAL A  18;ILE A  27;GLU A  85","None","1.00A","4a97I-4p27A:undetectable","4a97I-4p27A:18.57"],["5X7P_B_ACRB1431_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","4p27","VENOM ALLERGEN-LIKE (VAL) 4 PROTEIN","Schistosoma mansoni",4,"HIS A  15;ASP A 144;GLY A  75;ASN A  77","None","1.43A","5x7pB-4p27A:undetectable","5x7pB-4p27A:7.86"]]