SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
(Escherichia
coli) 		4 / 6 PHE B  62
ILE B  51
VAL B  49
PHE B  67
 None
 0.94A 2cizA-4p2cB:
undetectable		 2cizA-4p2cB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		4 / 8 GLY G 108
ASN G  96
ALA G 101
GLU G 100
 None
 0.94A 2x0pA-4p2cG:
undetectable		 2x0pA-4p2cG:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
(Escherichia
coli) 		3 / 3 GLY B  59
TYR B  28
SER B  60
 None
 0.67A 2xatA-4p2cB:
undetectable		 2xatA-4p2cB:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Escherichia
coli;
Lama
glama) 		5 / 12 ASN B  31
GLY B  61
SER G  53
GLY G  26
MET G  34
 None
 1.35A 2y6rC-4p2cB:
undetectable		 2y6rC-4p2cB:
11.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		5 / 12 MET G  34
ARG G  71
ASN G  76
VAL G  78
ALA G  97
 None
 0.76A 3qxtA-4p2cG:
19.2		 3qxtA-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		5 / 12 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
 None
 0.68A 3qxtA-4p2cG:
19.2		 3qxtA-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		7 / 12 VAL G   2
LEU G   4
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
 None
 0.63A 3qxtB-4p2cG:
19.4		 3qxtB-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		7 / 12 VAL G   2
MET G  34
ARG G  71
ASN G  73
VAL G  78
ALA G  97
TYR G 111
 None
 0.58A 3qxvA-4p2cG:
18.9		 3qxvA-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 12 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
 None
 0.59A 3qxvB-4p2cG:
18.9		 3qxvB-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 11 VAL G   2
MET G  34
ARG G  71
ASN G  73
VAL G  78
ALA G  97
 None
 0.57A 3qxvC-4p2cG:
19.1		 3qxvC-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 12 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
 None
 0.62A 3qxvD-4p2cG:
19.1		 3qxvD-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		5 / 12 MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
 None
 0.57A 3qxvE-4p2cG:
16.0		 3qxvE-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		5 / 12 SER G  27
MET G  34
VAL G  78
ALA G  97
TYR G 111
 None
 1.27A 3qxvE-4p2cG:
16.0		 3qxvE-4p2cG:
70.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
(Escherichia
coli) 		3 / 3 TYR B  28
ARG B  26
SER B  58
 None
 0.90A 4dr2I-4p2cB:
undetectable
4dr2J-4p2cB:
undetectable		 4dr2I-4p2cB:
21.98
4dr2J-4p2cB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
(Escherichia
coli) 		3 / 3 TYR B  28
ARG B  26
SER B  58
 None
 0.94A 4lf7I-4p2cB:
undetectable
4lf7J-4p2cB:
undetectable		 4lf7I-4p2cB:
21.98
4lf7J-4p2cB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4p2c SHIGA TOXIN 2E,
SUBUNIT B
(Escherichia
coli) 		3 / 3 TYR B  28
ARG B  26
SER B  58
 None
 0.94A 4lf8I-4p2cB:
undetectable
4lf8J-4p2cB:
undetectable		 4lf8I-4p2cB:
21.98
4lf8J-4p2cB:
22.43