SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 323
ASP A 325
GLY A 423
ILE A 422
VAL A 392
 None
None
GOL  A 520 (-3.2A)
None
None
 1.13A 1d4yA-4p2fA:
undetectable		 1d4yA-4p2fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A 355
ALA A 354
ASP A 365
VAL A 305
GLY A 368
VAL A 308
 EDO  A 507 (-3.4A)
EDO  A 507 (-4.2A)
EDO  A 515 (-2.9A)
None
None
EDO  A 502 (-4.8A)
 1.46A 1t7jA-4p2fA:
undetectable		 1t7jA-4p2fA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 345
PHE A 283
THR A 327
ALA A 330
PHE A 275
 None
None
EDO  A 503 (-3.9A)
None
None
 1.30A 2ij7A-4p2fA:
undetectable		 2ij7A-4p2fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 323
ASP A 325
GLY A 423
ILE A 422
VAL A 392
 None
None
GOL  A 520 (-3.2A)
None
None
 1.11A 2o4pA-4p2fA:
undetectable		 2o4pA-4p2fA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 396
VAL A 345
GLY A 346
MET A 377
 None
None
None
EDO  A 510 ( 4.7A)
 0.99A 2po5A-4p2fA:
undetectable		 2po5A-4p2fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 355
ALA A 354
ASP A 365
VAL A 305
GLY A 368
VAL A 308
 EDO  A 507 (-3.4A)
EDO  A 507 (-4.2A)
EDO  A 515 (-2.9A)
None
None
EDO  A 502 (-4.8A)
 1.50A 3el5B-4p2fA:
undetectable		 3el5B-4p2fA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 290
ALA A 320
ASP A 399
LEU A 396
LEU A 253
 PEG  A 519 (-3.2A)
None
None
None
None
 1.23A 3lcvB-4p2fA:
undetectable		 3lcvB-4p2fA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 396
ALA A 348
ARG A 395
LEU A 402
 None
None
None
EDO  A 513 (-4.2A)
 1.16A 3rd0A-4p2fA:
undetectable		 3rd0A-4p2fA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 390
GLU A 404
TYR A 393
GLU A 394
 EDO  A 510 (-4.9A)
None
EDO  A 513 (-4.8A)
None
 1.33A 3w9tA-4p2fA:
undetectable		 3w9tA-4p2fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 390
GLU A 404
TYR A 393
GLU A 394
 EDO  A 510 (-4.9A)
None
EDO  A 513 (-4.8A)
None
 1.35A 3w9tC-4p2fA:
undetectable		 3w9tC-4p2fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 390
GLU A 404
TYR A 393
GLU A 394
 EDO  A 510 (-4.9A)
None
EDO  A 513 (-4.8A)
None
 1.35A 3w9tD-4p2fA:
undetectable		 3w9tD-4p2fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 390
GLU A 404
TYR A 393
GLU A 394
 EDO  A 510 (-4.9A)
None
EDO  A 513 (-4.8A)
None
 1.34A 3w9tG-4p2fA:
undetectable		 3w9tG-4p2fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 352
ALA A 348
PRO A 311
ALA A 370
GLY A 350
 None
 1.28A 5tzoA-4p2fA:
undetectable		 5tzoA-4p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4p2f ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 352
ALA A 348
PRO A 311
ALA A 370
GLY A 350
 None
 1.26A 5tzoC-4p2fA:
undetectable		 5tzoC-4p2fA:
17.86