SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 4 VAL B 363
ALA B 250
LEU B 398
PHE B 254
 None
 1.12A 1q97B-4p37B:
undetectable		 1q97B-4p37B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 THR B 145
VAL B 147
VAL B 151
PHE B 326
PHE B 377
 None
 1.36A 2y03B-4p37B:
undetectable		 2y03B-4p37B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 THR B 145
VAL B 147
VAL B 151
PHE B 326
PHE B 377
 None
 1.37A 2y04B-4p37B:
undetectable		 2y04B-4p37B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 THR B 145
VAL B 147
VAL B 151
PHE B 326
PHE B 377
 None
 1.35A 3nyaA-4p37B:
undetectable		 3nyaA-4p37B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		3 / 3 LYS B 192
ARG B 189
ASP B  94
 None
 1.44A 3o7wA-4p37B:
undetectable		 3o7wA-4p37B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		3 / 3 ARG B 361
LEU B 244
THR B 297
 None
 0.82A 3oxcA-4p37B:
undetectable		 3oxcA-4p37B:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 6 GLY B 328
THR B 327
LEU B 323
GLU B 345
 PEG  B 604 ( 4.1A)
None
None
None
 0.96A 3ps9A-4p37B:
undetectable		 3ps9A-4p37B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 8 TYR B 344
ASP B 382
ALA B 379
TYR B 391
 None
 0.87A 3rodA-4p37B:
undetectable		 3rodA-4p37B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 9 ILE B 255
LEU B 398
PRO B 285
GLY B 247
MET B 287
 None
 1.44A 3w1wB-4p37B:
0.0		 3w1wB-4p37B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 5 TYR B 146
THR B 510
LEU B 495
THR B 327
 None
 1.39A 4mbsB-4p37B:
undetectable		 4mbsB-4p37B:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 HIS B 169
LEU B 172
LEU B 176
LEU B 369
TYR B 373
 None
None
None
None
PEG  B 602 ( 4.5A)
 1.11A 4xumA-4p37B:
undetectable		 4xumA-4p37B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 7 LYS B 235
TYR B 360
TYR B 362
LEU B 244
 None
 1.17A 4yv5A-4p37B:
undetectable		 4yv5A-4p37B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 7 LYS B 235
TYR B 360
TYR B 362
LEU B 244
 None
 1.11A 4yv5B-4p37B:
undetectable		 4yv5B-4p37B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 7 ASP B 105
THR B 101
TYR B 146
PRO B 100
 None
 1.22A 5b6iA-4p37B:
undetectable		 5b6iA-4p37B:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 4 LEU B 398
ARG B 256
ILE B 255
ILE B 281
 None
 1.18A 5dzk2-4p37B:
undetectable
5dzkM-4p37B:
undetectable
5dzkN-4p37B:
undetectable		 5dzk2-4p37B:
0.98
5dzkM-4p37B:
16.48
5dzkN-4p37B:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 5 LEU B 398
ARG B 256
ILE B 255
ILE B 281
 None
 1.09A 5dzk4-4p37B:
undetectable
5dzkg-4p37B:
undetectable
5dzkm-4p37B:
undetectable
5dzkn-4p37B:
undetectable		 5dzk4-4p37B:
0.98
5dzkg-4p37B:
16.42
5dzkm-4p37B:
16.48
5dzkn-4p37B:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 7 ALA B  72
THR B  71
TYR B  87
GLU B  96
 None
PEG  B 601 ( 4.6A)
None
None
 1.15A 5ecnA-4p37B:
undetectable		 5ecnA-4p37B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		4 / 8 TYR B 373
LEU B 201
LEU B 200
THR B  76
 PEG  B 602 ( 4.5A)
None
None
None
 0.90A 5hs6A-4p37B:
undetectable		 5hs6A-4p37B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		3 / 3 VAL B 121
GLU B  43
GLU B  48
 None
 0.93A 5jsdB-4p37B:
undetectable
5jsdC-4p37B:
undetectable		 5jsdB-4p37B:
23.22
5jsdC-4p37B:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 ILE B 395
ILE B 374
LEU B 369
LEU B 172
LEU B 176
 None
 1.02A 5tiwA-4p37B:
undetectable		 5tiwA-4p37B:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Megavirus
chiliensis) 		5 / 12 THR B 145
VAL B 147
VAL B 151
PHE B 326
PHE B 377
 None
 1.50A 6iblA-4p37B:
undetectable		 6iblA-4p37B:
19.03