SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC2_0 (ACTINOMYCIN D)	4p3c	HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2/15 (Mus musculus)	4 / 4	THR H 122 PRO H 152 THR H 121 PRO H 123	None	1.34A	1dsdC-4p3cH: undetectable	1dsdC-4p3cH: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC8_0 (ACTINOMYCIN D)	4p3c	HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2/15 (Mus musculus)	4 / 4	THR H 122 PRO H 152 THR H 121 PRO H 123	None	1.34A	1dsdC-4p3cH: undetectable	1dsdC-4p3cH: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V8B_C_ADNC2502_2 (ADENOSYLHOMOCYSTEINA SE)	4p3c	HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2/15 (Mus musculus)	3 / 3	GLU H 196 THR H 192 LEU H 164	None	0.61A	1v8bC-4p3cH: undetectable	1v8bC-4p3cH: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA501_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4p3c	HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2/15 (Mus musculus)	4 / 5	TYR H 94 LEU H 81 LEU H 86 ARG H 67	None	1.13A	4em2A-4p3cH: undetectable	4em2A-4p3cH: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUE_A_SAMA303_1 (CATECHOL O-METHYLTRANSFERASE)	4p3c	HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2/15 (Mus musculus)	4 / 5	TYR H 59 SER H 60 GLU H 46 ASP H 62	EDO H 307 (-4.6A) None None None	1.36A	4xueA-4p3cH: undetectable	4xueA-4p3cH: 20.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DSD_C_DVAC2_0","ACTINOMYCIN D","4p3c","HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2\/15","Mus musculus",4,"THR H 122;PRO H 152;THR H 121;PRO H 123","None","1.34A","1dsdC-4p3cH:undetectable","1dsdC-4p3cH:13.33"],["1DSD_C_DVAC8_0","ACTINOMYCIN D","4p3c","HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2\/15","Mus musculus",4,"THR H 122;PRO H 152;THR H 121;PRO H 123","None","1.34A","1dsdC-4p3cH:undetectable","1dsdC-4p3cH:13.33"],["1V8B_C_ADNC2502_2","ADENOSYLHOMOCYSTEINASE","4p3c","HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2\/15","Mus musculus",3,"GLU H 196;THR H 192;LEU H 164","None","0.61A","1v8bC-4p3cH:undetectable","1v8bC-4p3cH:19.33"],["4EM2_A_SALA501_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4p3c","HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2\/15","Mus musculus",4,"TYR H  94;LEU H  81;LEU H  86;ARG H  67","None","1.13A","4em2A-4p3cH:undetectable","4em2A-4p3cH:19.09"],["4XUE_A_SAMA303_1","CATECHOL O-METHYLTRANSFERASE","4p3c","HEAVY CHAIN FAB FRAGMENT OF ANTIBODY LEM-2\/15","Mus musculus",4,"TYR H  59;SER H  60;GLU H  46;ASP H  62","EDO H 307 (-4.6A);None;None;None","1.36A","4xueA-4p3cH:undetectable","4xueA-4p3cH:20.72"]]