SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		4 / 6 ALA A 139
LEU A 142
ALA A  73
THR A  72
 None
 0.62A 3b6hA-4p3gA:
undetectable		 3b6hA-4p3gA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		4 / 6 ALA A 139
LEU A 142
ALA A  73
THR A  72
 None
 0.63A 3b6hB-4p3gA:
undetectable		 3b6hB-4p3gA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		3 / 3 TYR A  20
LEU A  32
ARG A  24
 None
 0.76A 3sufB-4p3gA:
undetectable		 3sufB-4p3gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		3 / 3 PHE A 179
SER A 173
SER A 174
 None
 1.01A 3ufgB-4p3gA:
2.0		 3ufgB-4p3gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		5 / 12 ILE A  59
ILE A  54
ALA A 119
ALA A 135
LEU A  70
 None
 0.97A 3uvvA-4p3gA:
undetectable		 3uvvA-4p3gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		5 / 12 LEU A 116
LEU A 142
ALA A  73
LEU A  70
THR A   9
 None
 1.10A 5mioB-4p3gA:
undetectable		 5mioB-4p3gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
(Chaetomium
thermophilum) 		4 / 5 ILE A  59
SER A 125
ALA A 135
LEU A  70
 None
 1.05A 6dwnA-4p3gA:
undetectable		 6dwnA-4p3gA:
18.78