SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A  34
VAL A  36
THR A  55
VAL A 135
 None
 0.97A 1dz9A-4p3hA:
undetectable		 1dz9A-4p3hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A  34
VAL A  36
THR A  55
VAL A 135
 None
 0.96A 1o76B-4p3hA:
undetectable		 1o76B-4p3hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		6 / 9 LEU A 115
ILE A  65
GLY A 145
SER A 116
SER A  15
LEU A  25
 None
 1.22A 2qmmA-4p3hA:
undetectable		 2qmmA-4p3hA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		6 / 11 LEU A 115
ILE A  65
GLY A 145
SER A 116
SER A  15
LEU A  25
 None
 1.23A 2qmmA-4p3hA:
undetectable
2qmmB-4p3hA:
undetectable		 2qmmA-4p3hA:
20.56
2qmmB-4p3hA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 SER A 167
VAL A 164
PHE A  59
GLU A 168
 None
 1.41A 3n5tA-4p3hA:
undetectable
3n5tB-4p3hA:
undetectable		 3n5tA-4p3hA:
17.77
3n5tB-4p3hA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.46A 4k5jA-4p3hA:
undetectable
4k5jB-4p3hA:
undetectable		 4k5jA-4p3hA:
17.81
4k5jB-4p3hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.43A 5adlA-4p3hA:
undetectable
5adlB-4p3hA:
undetectable		 5adlA-4p3hA:
17.81
5adlB-4p3hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		5 / 10 ALA A 154
GLU A 155
LEU A 173
GLY A  57
LEU A  56
 None
 1.27A 5dxbA-4p3hA:
undetectable		 5dxbA-4p3hA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.45A 5fj3A-4p3hA:
undetectable
5fj3B-4p3hA:
undetectable		 5fj3A-4p3hA:
17.81
5fj3B-4p3hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		5 / 12 ALA A 154
GLU A 155
LEU A 173
GLY A  57
LEU A  56
 None
 1.12A 5gtrA-4p3hA:
undetectable		 5gtrA-4p3hA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.46A 5vv7A-4p3hA:
undetectable
5vv7B-4p3hA:
undetectable		 5vv7A-4p3hA:
17.81
5vv7B-4p3hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.43A 5vvnA-4p3hA:
undetectable
5vvnB-4p3hA:
undetectable		 5vvnA-4p3hA:
17.81
5vvnB-4p3hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 SER A 167
VAL A 164
PHE A  59
GLU A 168
 None
 1.45A 6av6A-4p3hA:
undetectable
6av6B-4p3hA:
undetectable		 6av6A-4p3hA:
19.05
6av6B-4p3hA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 SER A 167
VAL A 164
PHE A  59
GLU A 168
 None
 1.46A 6av7A-4p3hA:
undetectable
6av7B-4p3hA:
undetectable		 6av7A-4p3hA:
19.05
6av7B-4p3hA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4p3h KSHV PROTEASE
(Human
gammaherpesvirus
8) 		6 / 12 GLY A  57
GLY A   8
GLY A  69
VAL A 135
ALA A 154
PHE A 161
 None
 1.41A 6nj9K-4p3hA:
undetectable		 6nj9K-4p3hA:
18.85