SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		4 / 5 LEU A 504
SER A 513
LEU A 468
GLY A 481
 None
 1.13A 1a4lB-4p3iA:
undetectable		 1a4lB-4p3iA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 ALA A 384
VAL A 386
TRP A 333
 None
 0.99A 1c4dA-4p3iA:
undetectable
1c4dB-4p3iA:
undetectable		 1c4dA-4p3iA:
3.07
1c4dB-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 TRP A 333
ALA A 384
VAL A 386
 None
 0.77A 1c4dA-4p3iA:
undetectable
1c4dB-4p3iA:
undetectable		 1c4dA-4p3iA:
3.07
1c4dB-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 ALA A 384
VAL A 386
TRP A 333
 None
 0.92A 1c4dC-4p3iA:
undetectable
1c4dD-4p3iA:
undetectable		 1c4dC-4p3iA:
3.07
1c4dD-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 TRP A 333
ALA A 384
VAL A 386
 None
 0.92A 1c4dC-4p3iA:
undetectable
1c4dD-4p3iA:
undetectable		 1c4dC-4p3iA:
3.07
1c4dD-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 ALA A 441
VAL A 443
TRP A 398
 None
 0.81A 1gmkA-4p3iA:
undetectable
1gmkB-4p3iA:
undetectable		 1gmkA-4p3iA:
3.07
1gmkB-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		4 / 6 ILE A 491
ARG A 270
THR A 272
LEU A 273
 None
 0.96A 3ag1N-4p3iA:
undetectable
3ag1W-4p3iA:
undetectable		 3ag1N-4p3iA:
19.92
3ag1W-4p3iA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		4 / 8 ILE A 400
PRO A 401
HIS A 412
GLY A 279
 None
 0.88A 3em0B-4p3iA:
undetectable		 3em0B-4p3iA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		5 / 12 PRO A 362
PHE A 325
PRO A 326
LEU A 383
VAL A 386
 None
 1.46A 4a84A-4p3iA:
undetectable		 4a84A-4p3iA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		5 / 12 GLU A 450
ALA A 285
VAL A 288
SER A 431
ILE A 251
 None
 1.21A 4pd9A-4p3iA:
undetectable		 4pd9A-4p3iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		4 / 4 ILE A 417
PHE A 266
GLN A 267
ASP A 327
 None
 1.33A 4umjA-4p3iA:
undetectable		 4umjA-4p3iA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		3 / 3 VAL A 395
ARG A 290
PRO A 248
 None
 0.85A 5koxA-4p3iA:
undetectable		 5koxA-4p3iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		5 / 10 LEU A 242
ILE A 491
PHE A 429
ASN A 240
LEU A 480
 None
 1.21A 5y7pH-4p3iA:
undetectable		 5y7pH-4p3iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		5 / 12 VAL A 525
VAL A 427
PHE A 510
GLU A 482
ASN A 479
 None
 1.13A 6bqgA-4p3iA:
undetectable		 6bqgA-4p3iA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4p3i P DOMAIN OF VP1
(Norwalk
virus) 		4 / 5 LEU A 352
THR A 337
THR A 382
GLY A 381
 None
 1.27A 6gtqA-4p3iA:
undetectable		 6gtqA-4p3iA:
21.67