SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 10 PHE A 302
SER A 379
PHE A 319
THR A 366
LEU A 369
 None
 1.31A 1a8uB-4p3mA:
undetectable		 1a8uB-4p3mA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 GLU A  57
TYR A  55
PHE A 257
PRO A 258
 None
SO4  A 503 (-4.3A)
None
None
 1.49A 1dfoB-4p3mA:
51.2		 1dfoB-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.46A 1dfoB-4p3mA:
51.2		 1dfoB-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 GLU A  57
TYR A  55
PHE A 257
PRO A 258
 None
SO4  A 503 (-4.3A)
None
None
 1.49A 1dfoA-4p3mA:
51.2		 1dfoA-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.46A 1dfoA-4p3mA:
51.2		 1dfoA-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 GLU A  57
TYR A  55
PHE A 257
PRO A 258
 None
SO4  A 503 (-4.3A)
None
None
 1.50A 1dfoD-4p3mA:
51.1		 1dfoD-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.47A 1dfoD-4p3mA:
51.1		 1dfoD-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 GLU A  57
TYR A  55
PHE A 257
PRO A 258
 None
SO4  A 503 (-4.3A)
None
None
 1.50A 1dfoC-4p3mA:
51.2		 1dfoC-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.46A 1dfoC-4p3mA:
51.2		 1dfoC-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 GLU A  57
TYR A  64
PHE A 257
 None
 0.36A 1eqbB-4p3mA:
51.1		 1eqbB-4p3mA:
74.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 GLU A  57
TYR A  64
PHE A 257
 None
 0.34A 1eqbA-4p3mA:
51.0		 1eqbA-4p3mA:
74.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 GLU A  57
TYR A  64
PHE A 257
 None
 0.35A 1eqbD-4p3mA:
47.2		 1eqbD-4p3mA:
74.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 GLU A  57
TYR A  64
PHE A 257
 None
 0.35A 1eqbC-4p3mA:
51.0		 1eqbC-4p3mA:
74.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.19A 1t88B-4p3mA:
undetectable		 1t88B-4p3mA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 6 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.57A 2vmyA-4p3mA:
44.1		 2vmyA-4p3mA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
 None
 0.38A 2vmyB-4p3mA:
44.2		 2vmyB-4p3mA:
55.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 SER A 311
ALA A 295
GLY A 365
THR A 366
VAL A 344
 None
 1.06A 2zifB-4p3mA:
undetectable		 2zifB-4p3mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 7 ASN A  92
ALA A  78
ALA A  82
GLN A  94
 GOL  A 508 (-3.8A)
None
None
None
 0.75A 3a2qA-4p3mA:
undetectable		 3a2qA-4p3mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 10 ASP A 201
GLY A 237
GLY A 238
LEU A 239
VAL A 105
 None
 1.04A 3em4V-4p3mA:
undetectable		 3em4V-4p3mA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LUS_B_X8ZB1001_1
(ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 9 ASN A  92
ALA A  91
TYR A  59
PRO A 264
PRO A  95
 GOL  A 508 (-3.8A)
GOL  A 508 (-4.8A)
GOL  A 508 (-3.0A)
None
None
 1.40A 3lusA-4p3mA:
0.7
3lusB-4p3mA:
1.1		 3lusA-4p3mA:
17.90
3lusB-4p3mA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 SER A 301
SER A 379
LEU A  32
VAL A 344
PHE A 319
 None
 1.33A 3u9fB-4p3mA:
1.7
3u9fC-4p3mA:
undetectable		 3u9fB-4p3mA:
18.53
3u9fC-4p3mA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 PHE A 319
SER A 301
SER A 379
LEU A  32
VAL A 344
 None
 1.35A 3u9fJ-4p3mA:
undetectable
3u9fL-4p3mA:
undetectable		 3u9fJ-4p3mA:
18.53
3u9fL-4p3mA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 VAL A 410
ILE A 309
ILE A 364
VAL A 344
LEU A  32
 None
 0.90A 3w67B-4p3mA:
undetectable		 3w67B-4p3mA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 VAL A 410
ILE A 309
ILE A 364
VAL A 344
LEU A  32
 None
 0.84A 3w68D-4p3mA:
undetectable		 3w68D-4p3mA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 6 PHE A  86
ALA A 210
LEU A 232
THR A 231
 None
None
CL  A 505 (-3.8A)
None
 1.13A 4dtzB-4p3mA:
undetectable		 4dtzB-4p3mA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 6 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.12A 4g3rA-4p3mA:
undetectable		 4g3rA-4p3mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 6 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.16A 4g3rB-4p3mA:
undetectable		 4g3rB-4p3mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 5 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.16A 4l49A-4p3mA:
undetectable		 4l49A-4p3mA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 6 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.11A 4l4cA-4p3mA:
undetectable		 4l4cA-4p3mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 6 ASP A 293
ASN A 294
ALA A 370
TYR A 287
 None
 1.10A 4mdbA-4p3mA:
undetectable		 4mdbA-4p3mA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 GLN A 326
SER A 360
ASP A 322
 None
 0.94A 4qwpA-4p3mA:
undetectable
4qwpB-4p3mA:
undetectable		 4qwpA-4p3mA:
23.96
4qwpB-4p3mA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 SER A  97
VAL A  93
ALA A 104
LEU A 252
ASN A  92
 SO4  A 502 (-3.4A)
None
None
None
GOL  A 508 (-3.8A)
 0.95A 4x1kA-4p3mA:
undetectable
4x1kB-4p3mA:
undetectable		 4x1kA-4p3mA:
22.93
4x1kB-4p3mA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 ASN A 294
ARG A 372
ILE A  30
GLN A 378
LEU A 382
 None
 1.13A 5b8hA-4p3mA:
undetectable
5b8hB-4p3mA:
undetectable		 5b8hA-4p3mA:
23.04
5b8hB-4p3mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		5 / 12 GLN A 378
LEU A 382
ASN A 294
ARG A 372
ILE A  30
 None
 1.14A 5b8hA-4p3mA:
undetectable
5b8hB-4p3mA:
undetectable		 5b8hA-4p3mA:
23.04
5b8hB-4p3mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		4 / 8 ASP A 395
ARG A 305
VAL A 321
GLN A 377
 None
 0.86A 6fbvD-4p3mA:
undetectable		 6fbvD-4p3mA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 THR A 402
ALA A 392
LYS A 394
 GOL  A 510 ( 4.0A)
None
None
 0.47A 6fgcA-4p3mA:
undetectable		 6fgcA-4p3mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE
(Psychromonas
ingrahamii) 		3 / 3 THR A 402
ALA A 392
LYS A 394
 GOL  A 510 ( 4.0A)
None
None
 0.49A 6fgdA-4p3mA:
undetectable		 6fgdA-4p3mA:
21.99