SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4p3w FILAMIN-A
(Homo
sapiens) 		5 / 10 GLU A2282
ALA A2253
VAL A2255
TYR A2305
SER A2279
 None
 1.06A 4at2A-4p3wA:
0.0		 4at2A-4p3wA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4p3w FILAMIN-A
(Homo
sapiens) 		4 / 8 HIS A2315
PRO A2320
LYS A2310
ALA A2272
 None
 1.02A 4k0bB-4p3wA:
undetectable		 4k0bB-4p3wA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4p3w FILAMIN-A
(Homo
sapiens) 		4 / 8 HIS A2315
PRO A2320
LYS A2310
ALA A2272
 None
 1.03A 4l7iB-4p3wA:
undetectable		 4l7iB-4p3wA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p3w FILAMIN-A
(Homo
sapiens) 		4 / 7 ALA A2266
ASP A2290
ARG A2288
GLU A2286
 None
 0.83A 5bs8A-4p3wA:
undetectable
5bs8C-4p3wA:
undetectable
5bs8D-4p3wA:
undetectable		 5bs8A-4p3wA:
15.51
5bs8C-4p3wA:
15.51
5bs8D-4p3wA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p3w FILAMIN-A
(Homo
sapiens) 		4 / 7 ALA A2266
ASP A2290
ARG A2288
GLU A2286
 None
 0.73A 5btgA-4p3wA:
undetectable
5btgC-4p3wA:
undetectable
5btgD-4p3wA:
undetectable		 5btgA-4p3wA:
15.51
5btgC-4p3wA:
15.51
5btgD-4p3wA:
23.31