SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 6 LEU A 208
MET A 244
LEU A 260
HIS A 215
 None
 1.19A 1errB-4p3zA:
undetectable		 1errB-4p3zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 TYR A 148
TYR A 100
LEU A 115
LEU A 112
ILE A 136
 None
 1.39A 1fmlA-4p3zA:
undetectable		 1fmlA-4p3zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 8 GLN A 271
LEU A 220
LEU A 206
LEU A 196
 None
 0.89A 1hk2A-4p3zA:
2.3		 1hk2A-4p3zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 4 ILE A 185
ASP A 147
LEU A 141
ARG A 177
 None
 1.36A 2a7qA-4p3zA:
undetectable		 2a7qA-4p3zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 7 SER A 143
ASP A 147
LEU A 112
GLU A 111
 None
 1.10A 2cdqB-4p3zA:
undetectable		 2cdqB-4p3zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 5 LEU A 208
MET A 244
LEU A 260
HIS A 215
 None
 1.21A 2jfaA-4p3zA:
3.0		 2jfaA-4p3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 LEU A 115
GLY A 120
ASP A 127
LEU A 149
LEU A 146
 None
 0.83A 3cjtG-4p3zA:
undetectable		 3cjtG-4p3zA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 6 LEU A 332
VAL A 329
LEU A 288
ASP A 338
 None
 0.82A 3cs9D-4p3zA:
undetectable		 3cs9D-4p3zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 LEU A 115
GLY A 114
LEU A 112
GLN A 110
ILE A 136
 None
None
None
GOL  A 407 (-3.0A)
None
 0.86A 3gwvA-4p3zA:
undetectable		 3gwvA-4p3zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 LEU A 115
GLY A 114
GLN A 110
ILE A 136
ALA A 101
 None
None
GOL  A 407 (-3.0A)
None
GOL  A 407 (-2.7A)
 1.06A 3gwwA-4p3zA:
0.7		 3gwwA-4p3zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 LEU A 115
GLY A 114
LEU A 112
GLN A 110
ILE A 136
 None
None
None
GOL  A 407 (-3.0A)
None
 0.95A 3gwwA-4p3zA:
0.7		 3gwwA-4p3zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4p3z COPN
(Chlamydia
pneumoniae) 		3 / 3 GLU A 209
GLY A 212
THR A 211
 None
 0.57A 3iazA-4p3zA:
undetectable		 3iazA-4p3zA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 PHE A 280
ARG A 283
GLY A 342
ASP A 335
LEU A 344
 None
 1.34A 3iv6C-4p3zA:
undetectable		 3iv6C-4p3zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4p3z COPN
(Chlamydia
pneumoniae) 		3 / 3 ASN A 380
ASN A 382
GLU A 326
 None
 0.87A 3kpdB-4p3zA:
undetectable		 3kpdB-4p3zA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4p3z COPN
(Chlamydia
pneumoniae) 		3 / 3 VAL A 284
VAL A 329
SER A 310
 None
None
MLZ  A 313 ( 3.2A)
 0.66A 3n8xB-4p3zA:
1.4		 3n8xB-4p3zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4p3z COPN
(Chlamydia
pneumoniae) 		3 / 3 LYS A 161
ARG A 168
LYS A  99
 None
 1.09A 3okxA-4p3zA:
undetectable		 3okxA-4p3zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 5 LEU A 112
LEU A 115
LEU A 146
SER A 143
 None
 0.92A 3vhuA-4p3zA:
undetectable		 3vhuA-4p3zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 12 ILE A 180
ALA A 140
ILE A 185
LEU A 260
THR A 144
 None
 1.29A 4cd2A-4p3zA:
undetectable		 4cd2A-4p3zA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 7 ALA A 182
PRO A 139
GLU A 106
LEU A 186
 None
 0.93A 4iomA-4p3zA:
3.2		 4iomA-4p3zA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 7 LEU A 240
TYR A 207
THR A 178
LEU A 220
 None
 0.63A 5jq7B-4p3zA:
undetectable		 5jq7B-4p3zA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 8 LEU A 240
TYR A 207
GLU A 247
THR A 267
 None
 1.16A 6c71B-4p3zA:
undetectable		 6c71B-4p3zA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4p3z COPN
(Chlamydia
pneumoniae) 		4 / 5 LEU A 260
THR A 211
THR A 214
GLY A 212
 None
 1.18A 6gtqA-4p3zA:
undetectable		 6gtqA-4p3zA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4p3z COPN
(Chlamydia
pneumoniae) 		5 / 10 ARG A 113
ALA A  97
LEU A 112
GLY A 114
LEU A 208
 GOL  A 407 ( 4.3A)
None
None
None
None
 1.30A 6hqbA-4p3zA:
4.8
6hqbJ-4p3zA:
undetectable		 6hqbA-4p3zA:
11.69
6hqbJ-4p3zA:
8.09