SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 7 GLU A 553
LEU A 520
VAL A 576
LEU A 514
 None
 0.86A 1hk3A-4p42A:
undetectable		 1hk3A-4p42A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		3 / 3 PHE A 363
LEU A 471
MET A 445
 None
 0.90A 1mx1D-4p42A:
undetectable		 1mx1D-4p42A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 ILE A 390
SER A 399
TRP A 410
LEU A 463
LEU A 430
 None
 1.02A 1s19A-4p42A:
undetectable		 1s19A-4p42A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 6 GLY A 314
HIS A 203
ASN A 201
PHE A 207
 None
 0.83A 1xf1B-4p42A:
undetectable		 1xf1B-4p42A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 SER A 612
ARG A 548
PRO A 532
VAL A 576
ILE A 618
 None
 1.41A 2xpvA-4p42A:
undetectable		 2xpvA-4p42A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 LEU A 430
LEU A 369
ILE A 390
SER A 407
TRP A 460
 None
 1.12A 3aqiB-4p42A:
undetectable		 3aqiB-4p42A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 10 LEU A 276
ILE A 337
VAL A 339
VAL A 286
LEU A 289
 None
EGC  A 701 (-4.7A)
None
None
None
 0.75A 3ogpB-4p42A:
undetectable		 3ogpB-4p42A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 9 PHE A 461
LEU A 475
VAL A 451
LEU A 444
ILE A 446
 None
 1.11A 3tbgD-4p42A:
undetectable		 3tbgD-4p42A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 5 ASP A 432
GLU A 404
GLY A 382
ASP A 436
 None
 1.35A 3w9tD-4p42A:
undetectable		 3w9tD-4p42A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 LEU A 430
LEU A 369
ILE A 390
SER A 407
TRP A 460
 None
 1.24A 4f4dB-4p42A:
undetectable		 4f4dB-4p42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 PHE A 363
GLY A 388
ILE A 390
LEU A 471
PHE A 461
 None
 0.95A 4pd4C-4p42A:
undetectable		 4pd4C-4p42A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 10 LEU A 629
LEU A 478
VAL A 451
LEU A 448
VAL A 392
 None
 1.15A 4po0A-4p42A:
undetectable		 4po0A-4p42A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 5 PHE A 363
LEU A 369
GLY A 442
ILE A 390
 None
 0.90A 5ik1A-4p42A:
undetectable		 5ik1A-4p42A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 4 VAL A 466
GLY A 371
ASP A 438
ASP A 432
 None
 1.03A 6cjkC-4p42A:
2.5		 6cjkC-4p42A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 4p42 EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 4 PRO A 554
LEU A 520
VAL A 533
ARG A 548
 None
 1.44A 6fgdA-4p42A:
undetectable		 6fgdA-4p42A:
21.01