SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 6 GLY A  90
TYR A  32
ALA A  92
TYR A  33
 None
 1.03A 1dmaB-4p48A:
undetectable		 1dmaB-4p48A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 12 GLY A 233
ASP A 182
ALA A 228
SER A 238
LEU A 132
 None
 1.33A 1kiaD-4p48A:
undetectable		 1kiaD-4p48A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 12 TYR A  88
GLY A  34
GLY A  90
GLY A  65
ILE A 239
 None
 1.01A 2fk8A-4p48A:
undetectable		 2fk8A-4p48A:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 7 TYR A  36
PRO A  45
TYR A  88
TYR A 223
 None
 0.58A 2oldA-4p48A:
16.3
2oldB-4p48A:
16.2		 2oldA-4p48A:
35.61
2oldB-4p48A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 7 TYR A 223
TYR A  36
PRO A  45
TYR A  88
 None
 0.64A 2oldA-4p48A:
16.3
2oldB-4p48A:
16.2		 2oldA-4p48A:
35.61
2oldB-4p48A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 4 SER A  91
GLY A  90
GLY A  24
GLY A  22
 None
 0.91A 3bogB-4p48A:
undetectable
3bogD-4p48A:
undetectable		 3bogB-4p48A:
undetectable
3bogD-4p48A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		3 / 3 TYR A  88
TYR A 223
GLY A 172
 None
 0.72A 3eteB-4p48A:
undetectable
3eteD-4p48A:
undetectable
3eteF-4p48A:
undetectable		 3eteB-4p48A:
20.28
3eteD-4p48A:
20.28
3eteF-4p48A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 10 PRO A  98
GLY A 233
TYR A 234
GLY A  24
ALA A  92
 None
 1.14A 3pp7B-4p48A:
undetectable		 3pp7B-4p48A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 6 GLY A 102
TYR A  87
ALA A 103
TYR A  88
 None
 0.98A 4ae1A-4p48A:
3.5		 4ae1A-4p48A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 8 LEU A 146
ARG A 166
VAL A 248
VAL A 250
 None
 0.97A 4em2A-4p48A:
undetectable		 4em2A-4p48A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 8 ASP A 240
SER A 238
THR A  99
MET A 162
 None
 0.86A 4fo4A-4p48A:
undetectable		 4fo4A-4p48A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 12 GLY A 235
ASP A 237
ILE A 239
ALA A 225
GLN A 163
 None
 1.18A 4wh5A-4p48A:
undetectable		 4wh5A-4p48A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 12 GLY A 236
ASP A 237
ILE A 239
ALA A 225
GLN A 163
 None
 1.41A 4wh5A-4p48A:
undetectable		 4wh5A-4p48A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 8 GLY A 144
GLN A 140
LEU A 214
THR A 141
 None
 0.88A 5syjA-4p48A:
undetectable		 5syjA-4p48A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 7 GLY A  23
GLN A 163
ASP A 237
TYR A  32
 None
 1.12A 5vlmC-4p48A:
undetectable		 5vlmC-4p48A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		4 / 7 GLY A  23
GLN A 163
ASP A 237
TYR A  32
 None
 1.24A 5vlmG-4p48A:
undetectable		 5vlmG-4p48A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 10 LEU A 211
TYR A 222
ASP A 218
VAL A 192
GLY A 189
 None
 1.41A 5zbdA-4p48A:
undetectable		 5zbdA-4p48A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4p48 ANTIBODY SCFV 180
(Gallus
gallus) 		5 / 10 LEU A 211
TYR A 222
ASP A 218
VAL A 192
GLY A 189
 None
 1.39A 5zbdB-4p48A:
undetectable		 5zbdB-4p48A:
21.54