SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.28A 1zzuA-4p49A:
undetectable
1zzuB-4p49A:
undetectable		 1zzuA-4p49A:
21.88
1zzuB-4p49A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 TYR A  30
PRO A  39
TYR A  82
TYR A 216
 None
 0.71A 2oldA-4p49A:
17.8
2oldB-4p49A:
17.8		 2oldA-4p49A:
35.74
2oldB-4p49A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.24A 3jx2A-4p49A:
undetectable
3jx2B-4p49A:
undetectable		 3jx2A-4p49A:
21.78
3jx2B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.28A 3jx2A-4p49A:
undetectable
3jx2B-4p49A:
undetectable		 3jx2A-4p49A:
21.78
3jx2B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.25A 3jx3A-4p49A:
undetectable
3jx3B-4p49A:
undetectable		 3jx3A-4p49A:
21.78
3jx3B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.31A 3jx4A-4p49A:
undetectable
3jx4B-4p49A:
undetectable		 3jx4A-4p49A:
21.78
3jx4B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.26A 3jx5A-4p49A:
undetectable
3jx5B-4p49A:
undetectable		 3jx5A-4p49A:
21.78
3jx5B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.21A 3jx6A-4p49A:
undetectable
3jx6B-4p49A:
undetectable		 3jx6A-4p49A:
21.78
3jx6B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.25A 3jx6A-4p49A:
undetectable
3jx6B-4p49A:
undetectable		 3jx6A-4p49A:
21.78
3jx6B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 11 TYR A 216
THR A 214
LEU A 165
GLY A 164
ASP A  36
 None
 1.28A 3lxiB-4p49A:
undetectable		 3lxiB-4p49A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.22A 3nljA-4p49A:
undetectable
3nljB-4p49A:
undetectable		 3nljA-4p49A:
21.78
3nljB-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.23A 3nljA-4p49A:
undetectable
3nljB-4p49A:
undetectable		 3nljA-4p49A:
21.78
3nljB-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.25A 3nlpA-4p49A:
undetectable
3nlpB-4p49A:
undetectable		 3nlpA-4p49A:
21.78
3nlpB-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.28A 3nlqA-4p49A:
undetectable
3nlqB-4p49A:
undetectable		 3nlqA-4p49A:
21.78
3nlqB-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.25A 3nlrA-4p49A:
undetectable
3nlrB-4p49A:
undetectable		 3nlrA-4p49A:
21.78
3nlrB-4p49A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		6 / 12 VAL A 122
ALA A 144
MET A 154
ARG A 193
ASN A 195
VAL A 200
 None
 0.89A 3qxvA-4p49A:
21.7		 3qxvA-4p49A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		6 / 11 VAL A 122
ALA A 144
MET A 154
ARG A 193
ASN A 195
VAL A 200
 None
 0.93A 3qxvC-4p49A:
22.0		 3qxvC-4p49A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 12 VAL A 122
ALA A 144
MET A 154
ARG A 193
VAL A 200
 None
 0.91A 3qxvD-4p49A:
21.7		 3qxvD-4p49A:
51.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 6 GLY A  94
TYR A  81
ALA A  95
TYR A  82
 None
 1.00A 4ae1A-4p49A:
3.7		 4ae1A-4p49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 10 TYR A 216
THR A 214
LEU A 165
GLY A 164
ASP A  36
 None
 1.35A 4c9nB-4p49A:
undetectable		 4c9nB-4p49A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 9 TYR A 216
THR A 214
LEU A 165
GLY A 164
VAL A  80
 None
 1.36A 4c9pA-4p49A:
undetectable		 4c9pA-4p49A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.27A 4cx3A-4p49A:
undetectable
4cx3B-4p49A:
undetectable		 4cx3A-4p49A:
21.78
4cx3B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 8 LEU A 138
ARG A 158
VAL A 240
VAL A 242
 None
 0.93A 4em2A-4p49A:
undetectable		 4em2A-4p49A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 11 GLY A  94
GLY A  84
ALA A   1
LEU A   2
TRP A  86
 None
None
None
None
SO4  A 303 ( 3.9A)
 1.18A 4l8fB-4p49A:
undetectable		 4l8fB-4p49A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		5 / 12 GLY A  28
PHE A  57
ASN A  47
ALA A 229
ASN A 227
 None
None
None
None
SO4  A 301 ( 4.0A)
 1.39A 4pclB-4p49A:
undetectable		 4pclB-4p49A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.26A 5addA-4p49A:
undetectable
5addB-4p49A:
undetectable		 5addA-4p49A:
21.78
5addB-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 GLU A  78
VAL A 101
ARG A  56
VAL A  16
 None
 1.27A 5adeA-4p49A:
undetectable
5adeB-4p49A:
undetectable		 5adeA-4p49A:
21.78
5adeB-4p49A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 8 TYR A  30
GLY A  84
GLY A  91
PHE A  93
 None
 0.16A 5albL-4p49A:
17.7		 5albL-4p49A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 8 TYR A  30
GLY A  84
GLY A  91
PHE A  93
 None
 0.23A 5alcL-4p49A:
18.5		 5alcL-4p49A:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 ALA A 213
THR A 212
VAL A 240
GLU A 210
 None
 0.76A 5ecmD-4p49A:
undetectable		 5ecmD-4p49A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 ALA A 213
THR A 212
VAL A 240
GLU A 210
 None
 0.80A 5ecoD-4p49A:
undetectable		 5ecoD-4p49A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p49 ANTIBODY SCFV B8
(Gallus
gallus) 		4 / 7 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.29A 5g0pA-4p49A:
undetectable
5g0pB-4p49A:
undetectable		 5g0pA-4p49A:
21.78
5g0pB-4p49A:
21.78