SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  99
PHE A  55
TRP A  59
 None
 0.83A 1r15C-4p4gA:
2.4		 1r15C-4p4gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  99
PHE A  55
TRP A  59
 None
 0.83A 1r15F-4p4gA:
2.5		 1r15F-4p4gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  99
PHE A  55
TRP A  59
 None
 0.84A 1r15G-4p4gA:
2.5		 1r15G-4p4gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  99
PHE A  55
TRP A  59
 None
 0.84A 1r15H-4p4gA:
2.5		 1r15H-4p4gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 135
PRO A 130
ASP A 105
THR A 191
 None
None
SKM  A 301 (-2.8A)
None
 1.19A 2aouB-4p4gA:
4.9		 2aouB-4p4gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  75
VAL A  62
LEU A  11
ALA A  72
 None
 1.07A 2e1qA-4p4gA:
undetectable		 2e1qA-4p4gA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  15
VAL A  64
VAL A  10
ARG A  40
 None
 1.17A 4m6tA-4p4gA:
undetectable		 4m6tA-4p4gA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 215
HIS A  17
ASP A 105
ASP A 102
 SKM  A 301 (-4.5A)
None
SKM  A 301 (-2.8A)
None
 1.50A 4qdjA-4p4gA:
5.7		 4qdjA-4p4gA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 105
ALA A 132
THR A 128
THR A 191
 SKM  A 301 (-2.8A)
None
None
None
 1.49A 4w5tA-4p4gA:
undetectable		 4w5tA-4p4gA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 105
ALA A 132
THR A 128
THR A 191
 SKM  A 301 (-2.8A)
None
None
None
 1.49A 4z4fA-4p4gA:
undetectable		 4z4fA-4p4gA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 178
THR A 168
ASP A 143
LEU A 204
 BR  A 305 ( 4.8A)
None
None
None
 1.04A 5jq7B-4p4gA:
undetectable		 5jq7B-4p4gA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 141
ILE A 144
VAL A 187
ALA A 120
 None
 0.49A 5osrA-4p4gA:
undetectable		 5osrA-4p4gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 8 SER A  20
HIS A  24
PHE A 251
THR A 104
 SKM  A 301 (-2.6A)
None
None
None
 1.41A 5u6nA-4p4gA:
2.1		 5u6nA-4p4gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 6 SER A  20
HIS A  24
PHE A 251
THR A 104
 SKM  A 301 (-2.6A)
None
None
None
 1.41A 5u6nB-4p4gA:
4.6		 5u6nB-4p4gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  40
ILE A  15
SER A  18
 None
None
SKM  A 301 (-2.4A)
 0.75A 5zw2A-4p4gA:
undetectable		 5zw2A-4p4gA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)
(Mycobacterium
tuberculosis) 		4 / 4 PRO A 130
MET A 239
GLY A 236
VAL A 189
 None
 1.17A 6ak3A-4p4gA:
undetectable		 6ak3A-4p4gA:
14.58