SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 9 LEU A 165
VAL A 195
TYR A 242
LEU A 225
TYR A 164
 None
 1.49A 1ikvA-4p4oA:
3.4		 1ikvA-4p4oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 12 VAL A 354
LEU A 313
PHE A 314
LEU A 316
GLU A 338
 None
 1.47A 1mmkA-4p4oA:
undetectable		 1mmkA-4p4oA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		4 / 4 GLY A 341
SER A 279
VAL A 212
LEU A 240
 None
 1.26A 1yajB-4p4oA:
undetectable		 1yajB-4p4oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		3 / 3 VAL A 122
ASP A 123
GLU A  98
 None
 0.73A 2qeuA-4p4oA:
undetectable		 2qeuA-4p4oA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		3 / 3 VAL A 122
ASP A 123
GLU A  98
 None
 0.73A 2qeuC-4p4oA:
undetectable		 2qeuC-4p4oA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 12 LEU A 248
LEU A 225
ALA A 197
VAL A 270
ILE A 181
 None
 1.08A 4x1yB-4p4oA:
undetectable		 4x1yB-4p4oA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 12 ALA A 283
ASP A 271
PHE A 287
GLY A 183
SER A 184
 None
None
None
D3T  A 401 (-3.2A)
D3T  A 401 (-2.5A)
 1.10A 5hfjE-4p4oA:
undetectable		 5hfjE-4p4oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		4 / 7 GLY A 193
PHE A 191
SER A 158
ASN A 150
 D3T  A 401 (-3.7A)
None
None
None
 0.80A 5n5dB-4p4oA:
undetectable		 5n5dB-4p4oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 10 ALA A 110
LEU A 113
LEU A 135
VAL A 102
ILE A 143
 None
 1.11A 5v02B-4p4oA:
undetectable
5v02R-4p4oA:
undetectable		 5v02B-4p4oA:
12.47
5v02R-4p4oA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 10 ARG A 140
ALA A 109
LEU A 125
VAL A 102
GLY A 142
 None
 1.27A 5zbdA-4p4oA:
undetectable		 5zbdA-4p4oA:
22.89