SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 PHE A 269
TYR A 275
LEU A 271
THR A 226
 None
 1.24A 1rmtB-4p4sA:
1.9		 1rmtB-4p4sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 PHE B 269
TYR B 275
LEU B 271
THR B 226
 None
 1.25A 1rmtB-4p4sB:
undetectable		 1rmtB-4p4sB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 ALA A 146
GLY A 156
GLY A 152
ILE A 150
CYH A 105
 None
 1.04A 1x1aA-4p4sA:
undetectable		 1x1aA-4p4sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 ALA B 146
GLY B 156
GLY B 152
ILE B 150
CYH B 105
 None
 1.06A 1x1aA-4p4sB:
2.3		 1x1aA-4p4sB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 LEU A 174
LEU A 111
LEU A  87
LEU A 323
 None
 1.01A 2ab2A-4p4sA:
undetectable		 2ab2A-4p4sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 LEU B 174
LEU B 111
LEU B  87
LEU B 323
 None
 1.03A 2ab2A-4p4sB:
undetectable		 2ab2A-4p4sB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 SER A 230
ARG A 208
LEU A 179
ILE A  76
SER A 213
 None
 1.32A 2fj1A-4p4sA:
undetectable		 2fj1A-4p4sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 SER B 230
ARG B 208
LEU B 179
ILE B  76
SER B 213
 None
 1.31A 2fj1A-4p4sB:
2.5		 2fj1A-4p4sB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 ILE A  73
ILE A 212
ILE A 243
VAL A 320
VAL A 278
 None
 1.07A 2ygoA-4p4sA:
undetectable		 2ygoA-4p4sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR A 225
SER B  80
LYS B  83
 None
GCP  B 701 (-4.5A)
GCP  B 701 (-2.5A)
 1.20A 3aocC-4p4sA:
undetectable		 3aocC-4p4sA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR B 225
SER A  80
LYS A  83
 None
GCP  A 401 (-4.4A)
GCP  A 401 (-2.6A)
 1.16A 3aocC-4p4sB:
3.0		 3aocC-4p4sB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 LEU B 179
THR B 183
ILE B 182
SER B  80
GLN B  79
 None
None
None
GCP  B 701 (-4.5A)
GCP  B 701 (-3.8A)
 1.42A 3g4lD-4p4sB:
undetectable		 3g4lD-4p4sB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 5 LEU A 201
ARG A 208
LEU A 179
PRO A 106
 None
 1.29A 3onnA-4p4sA:
2.5		 3onnA-4p4sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 5 LEU B 201
ARG B 208
LEU B 179
PRO B 106
 None
 1.29A 3onnA-4p4sB:
2.6		 3onnA-4p4sB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP A 262
GLU A 315
SER B  99
 None
None
GCP  B 701 ( 4.2A)
 0.70A 3p2kA-4p4sA:
undetectable		 3p2kA-4p4sA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B 262
GLU B 315
SER A  99
 None
None
GCP  A 401 ( 4.4A)
 0.72A 3p2kA-4p4sB:
undetectable		 3p2kA-4p4sB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 10 VAL A 216
ALA A 228
SER A  80
VAL A  75
THR A 226
 None
None
GCP  A 401 (-4.4A)
None
None
 1.30A 4eilB-4p4sA:
undetectable		 4eilB-4p4sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 10 VAL B 216
ALA B 228
SER B  80
VAL B  75
THR B 226
 None
None
GCP  B 701 (-4.5A)
None
None
 1.31A 4eilB-4p4sB:
undetectable		 4eilB-4p4sB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 4 PRO A 180
LEU A 179
ILE A 177
ARG A 208
 None
 1.04A 4f4dA-4p4sA:
undetectable		 4f4dA-4p4sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 4 PRO B 180
LEU B 179
ILE B 177
ARG B 208
 None
 1.03A 4f4dA-4p4sB:
undetectable		 4f4dA-4p4sB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 10 VAL A 216
ALA A 228
SER A  80
VAL A  75
THR A 226
 None
None
GCP  A 401 (-4.4A)
None
None
 1.34A 4kyaC-4p4sA:
undetectable		 4kyaC-4p4sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 VAL A 216
ALA A 228
SER A  80
VAL A  75
THR A 226
 None
None
GCP  A 401 (-4.4A)
None
None
 1.35A 4kyaE-4p4sA:
undetectable		 4kyaE-4p4sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 VAL A 216
ALA A 228
SER A  80
VAL A  75
THR A 226
 None
None
GCP  A 401 (-4.4A)
None
None
 1.35A 4kyaG-4p4sA:
undetectable		 4kyaG-4p4sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 PHE A 309
ASP A 311
ALA A 318
VAL A 264
ASP A 262
 None
 1.20A 4uuuA-4p4sA:
undetectable
4uuuB-4p4sA:
undetectable		 4uuuA-4p4sA:
20.45
4uuuB-4p4sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 PHE B 309
ASP B 311
ALA B 318
VAL B 264
ASP B 262
 None
 1.20A 4uuuA-4p4sB:
undetectable
4uuuB-4p4sB:
undetectable		 4uuuA-4p4sB:
18.55
4uuuB-4p4sB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 LEU A 331
LEU A 327
GLU A 330
ILE A  73
 None
 0.86A 4ww7A-4p4sA:
undetectable		 4ww7A-4p4sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 LEU B 331
LEU B 327
GLU B 330
ILE B  73
 None
 0.76A 4ww7A-4p4sB:
undetectable		 4ww7A-4p4sB:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 ILE A 245
LEU A 327
HIS A 270
ASN A 266
GLY A 244
 None
 1.23A 5k7uA-4p4sA:
undetectable		 5k7uA-4p4sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		3 / 3 LYS A  70
LYS A 337
SER A 338
 None
 1.22A 5odiA-4p4sA:
undetectable		 5odiA-4p4sA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 8 GLU A  88
PHE A 302
SER A 219
PHE A 303
 None
 1.10A 5y2tB-4p4sA:
undetectable		 5y2tB-4p4sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 8 GLU B  88
PHE B 302
SER B 219
PHE B 303
 None
 1.09A 5y2tB-4p4sB:
undetectable		 5y2tB-4p4sB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 ALA A 146
ASP A 135
ILE A 133
ILE A 166
 None
 0.92A 6fbnA-4p4sA:
undetectable		 6fbnA-4p4sA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 ALA B 146
ASP B 135
ILE B 133
ILE B 166
 None
 0.92A 6fbnA-4p4sB:
undetectable		 6fbnA-4p4sB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 8 ASP A 262
HIS A 306
ARG A 265
ASP A 311
 None
 0.98A 6mn4D-4p4sA:
undetectable		 6mn4D-4p4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 8 ASP B 262
HIS B 306
ARG B 265
ASP B 311
 None
 0.97A 6mn4D-4p4sB:
undetectable		 6mn4D-4p4sB:
22.47