SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 7 GLY A 106
ILE A 110
ALA A  60
ILE A  46
 None
 0.74A 1n49A-4p52A:
undetectable		 1n49A-4p52A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 219
GLY A 213
MET A 226
PRO A 168
 None
 0.95A 1rxcE-4p52A:
undetectable		 1rxcE-4p52A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 219
GLY A 213
MET A 226
PRO A 168
 None
 0.95A 1rxcI-4p52A:
undetectable		 1rxcI-4p52A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLU A  33
GLY A  31
CYH A 146
ALA A 101
ALA A 100
 None
 1.20A 2br4B-4p52A:
undetectable		 2br4B-4p52A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 5 LEU A 269
PHE A 151
VAL A  13
ALA A 173
 None
 1.18A 2cizA-4p52A:
undetectable		 2cizA-4p52A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 5 LEU A 250
ALA A 268
ILE A 279
SER A 270
 None
 1.08A 2othA-4p52A:
undetectable		 2othA-4p52A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 7 ILE A 259
ARG A 235
PRO A  30
GLY A  97
 None
 1.17A 2pnjB-4p52A:
undetectable		 2pnjB-4p52A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 9 VAL A  22
TRP A 204
VAL A 231
ASN A  15
GLY A  19
 None
 1.44A 3km6B-4p52A:
undetectable		 3km6B-4p52A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 11 VAL A 245
ILE A 279
GLY A 280
THR A 174
ALA A 268
 None
 0.95A 3kw2B-4p52A:
undetectable		 3kw2B-4p52A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		3 / 3 HIS A 229
SER A 236
GLU A 232
 None
 0.50A 3s8pA-4p52A:
undetectable		 3s8pA-4p52A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 130
ALA A 127
ALA A 100
VAL A 143
ALA A 134
 None
 1.24A 4df3A-4p52A:
undetectable		 4df3A-4p52A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 130
ALA A 127
ALA A 100
VAL A 143
ALA A 134
 None
 1.21A 4df3B-4p52A:
undetectable		 4df3B-4p52A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 219
GLY A 213
MET A 226
PRO A 168
 None
 0.98A 4e1vE-4p52A:
undetectable		 4e1vE-4p52A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 7 ARG A  55
GLY A  54
ILE A  49
ASN A  63
 None
 1.04A 4g0vA-4p52A:
undetectable		 4g0vA-4p52A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 9 LEU A  70
VAL A 107
ILE A 110
LEU A 114
GLY A  81
 None
 0.98A 4kukA-4p52A:
undetectable		 4kukA-4p52A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 214
PHE A 151
ILE A 222
ALA A 173
VAL A  16
 None
 1.10A 4nkxC-4p52A:
undetectable		 4nkxC-4p52A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		5 / 12 ALA A  14
PHE A  20
THR A 184
LEU A 191
PRO A 192
 None
 0.96A 4p3qA-4p52A:
undetectable		 4p3qA-4p52A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		3 / 3 GLY A 305
PRO A 306
ALA A 105
 None
 0.35A 4qn9B-4p52A:
undetectable		 4qn9B-4p52A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 5 PHE A 242
LEU A 250
GLY A 256
ILE A 259
 None
 0.81A 5ik1A-4p52A:
1.3		 5ik1A-4p52A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 6 VAL A  16
LEU A 210
LEU A 214
LEU A 255
 None
 1.00A 6f6sA-4p52A:
undetectable
6f6sB-4p52A:
undetectable		 6f6sA-4p52A:
14.43
6f6sB-4p52A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 4 ALA A 249
ALA A 252
ALA A 254
ALA A 268
 None
 0.83A 6gtqA-4p52A:
undetectable
6gtqB-4p52A:
undetectable		 6gtqA-4p52A:
19.87
6gtqB-4p52A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		4 / 4 ALA A 254
ALA A 268
ALA A 249
ALA A 252
 None
 0.83A 6gtqA-4p52A:
undetectable
6gtqB-4p52A:
undetectable		 6gtqA-4p52A:
19.87
6gtqB-4p52A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4p52 HOMOSERINE KINASE
(Cytophaga
hutchinsonii) 		3 / 3 ASP A  52
SER A  98
SER A 102
 None
 0.82A 6mxtA-4p52A:
undetectable		 6mxtA-4p52A:
21.56