SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 7 VAL A 382
LEU A 314
SER A 312
LEU A 321
 None
 0.83A 1j8uA-4p53A:
undetectable		 1j8uA-4p53A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 10 GLU A 101
VAL A 135
GLY A 134
ASN A 181
HIS A 284
 NAI  A 502 (-2.8A)
NAI  A 502 (-3.6A)
NAI  A 502 (-3.1A)
NAI  A 502 (-3.7A)
ZN  A 501 (-3.3A)
 1.29A 1v3qE-4p53A:
2.7		 1v3qE-4p53A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 5 GLY A 262
LYS A 221
LEU A 279
PRO A 269
 None
 1.44A 2dqyA-4p53A:
2.2		 2dqyA-4p53A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 10 ALA A  63
LEU A  81
LEU A  52
LEU A  56
LEU A  85
 None
 1.13A 2riwA-4p53A:
undetectable
2riwB-4p53A:
undetectable		 2riwA-4p53A:
20.78
2riwB-4p53A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 219
GLY A 374
LEU A 215
ALA A 223
GLY A 327
 None
 0.97A 2vmyA-4p53A:
3.8		 2vmyA-4p53A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 7 ILE A 214
LEU A 215
VAL A 332
GLY A 233
 None
 0.68A 2wd9A-4p53A:
4.0		 2wd9A-4p53A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 8 ILE A 214
LEU A 215
VAL A 332
GLY A 233
 None
 0.66A 2wd9B-4p53A:
4.2		 2wd9B-4p53A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 10 ALA A  63
LEU A  81
LEU A  52
LEU A  56
LEU A  85
 None
 1.15A 2xn6A-4p53A:
undetectable
2xn6B-4p53A:
undetectable		 2xn6A-4p53A:
23.49
2xn6B-4p53A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 GLY A 327
SER A 312
LEU A 394
LEU A 215
LEU A 219
 None
 1.05A 3cs8A-4p53A:
undetectable		 3cs8A-4p53A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 ASN A 175
VAL A 109
LEU A 142
ILE A 139
THR A 172
 None
 1.33A 3em0B-4p53A:
undetectable		 3em0B-4p53A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.18A 3ko0A-4p53A:
undetectable
3ko0B-4p53A:
undetectable
3ko0C-4p53A:
undetectable
3ko0D-4p53A:
undetectable		 3ko0A-4p53A:
12.62
3ko0B-4p53A:
12.62
3ko0C-4p53A:
12.62
3ko0D-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 PHE A 119
LEU A  85
PHE A  92
ILE A  67
LEU A 129
 None
 1.14A 3ko0G-4p53A:
undetectable
3ko0H-4p53A:
undetectable
3ko0I-4p53A:
undetectable
3ko0J-4p53A:
undetectable		 3ko0G-4p53A:
12.62
3ko0H-4p53A:
12.62
3ko0I-4p53A:
12.62
3ko0J-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 11 PHE A 119
LEU A 129
LEU A  85
PHE A  92
ILE A  67
 None
 1.17A 3ko0A-4p53A:
undetectable
3ko0B-4p53A:
undetectable
3ko0I-4p53A:
undetectable
3ko0J-4p53A:
undetectable		 3ko0A-4p53A:
12.62
3ko0B-4p53A:
12.62
3ko0I-4p53A:
12.62
3ko0J-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.19A 3ko0K-4p53A:
undetectable
3ko0L-4p53A:
undetectable
3ko0S-4p53A:
undetectable
3ko0T-4p53A:
undetectable		 3ko0K-4p53A:
12.62
3ko0L-4p53A:
12.62
3ko0S-4p53A:
12.62
3ko0T-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 129
LEU A  85
PHE A  92
ILE A  67
PHE A 119
 None
 1.20A 3ko0K-4p53A:
undetectable
3ko0L-4p53A:
undetectable
3ko0M-4p53A:
undetectable
3ko0N-4p53A:
undetectable		 3ko0K-4p53A:
12.62
3ko0L-4p53A:
12.62
3ko0M-4p53A:
12.62
3ko0N-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.20A 3ko0M-4p53A:
undetectable
3ko0N-4p53A:
undetectable
3ko0O-4p53A:
undetectable
3ko0P-4p53A:
undetectable		 3ko0M-4p53A:
12.62
3ko0N-4p53A:
12.62
3ko0O-4p53A:
12.62
3ko0P-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 PHE A 282
ILE A 373
ALA A 223
ALA A 259
GLU A 213
 None
None
None
None
ZN  A 501 (-2.6A)
 1.05A 3nxuA-4p53A:
undetectable		 3nxuA-4p53A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 6 LEU A 267
HIS A 284
HIS A 300
GLU A 213
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-2.6A)
 0.98A 4pahA-4p53A:
undetectable		 4pahA-4p53A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 THR A 393
LEU A 391
ALA A 390
LEU A 314
LEU A 326
 None
 1.02A 4xi3C-4p53A:
undetectable		 4xi3C-4p53A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 ALA A 166
GLY A 132
GLY A 134
ALA A 130
ARG A 155
 NAI  A 502 (-3.5A)
None
NAI  A 502 (-3.1A)
None
None
 1.00A 5c0oG-4p53A:
3.4		 5c0oG-4p53A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 8 ILE A 139
GLY A 133
THR A 158
LEU A 129
 None
NAI  A 502 (-3.2A)
NAI  A 502 (-3.5A)
None
 0.82A 5hs1A-4p53A:
undetectable		 5hs1A-4p53A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		5 / 12 VAL A 255
THR A 254
VAL A 237
ALA A 234
LEU A 236
 None
 1.10A 5kocA-4p53A:
undetectable		 5kocA-4p53A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 7 VAL A 358
PRO A 370
LEU A 219
LEU A 369
 None
 1.12A 6aycA-4p53A:
undetectable		 6aycA-4p53A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4p53 CYCLASE
(Streptomyces
hygroscopicus) 		4 / 6 LEU A 267
HIS A 284
HIS A 300
GLU A 213
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-2.6A)
 1.01A 6pahA-4p53A:
undetectable		 6pahA-4p53A:
21.77