SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 HIS A 277
GLU A 212
ALA A 114
HIS A 238
 None
RMN  A 401 ( 4.4A)
None
RMN  A 401 ( 4.4A)
 1.29A 1errA-4p56A:
undetectable
1errB-4p56A:
undetectable		 1errA-4p56A:
21.90
1errB-4p56A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 GLU A  52
LEU A 339
ASP A 112
PHE A  45
TYR A 144
 None
 1.25A 1u65A-4p56A:
0.0		 1u65A-4p56A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 ASP A 340
GLY A 147
ALA A 120
ILE A 336
 None
 0.85A 2aofA-4p56A:
undetectable		 2aofA-4p56A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 PHE A  45
TRP A 274
LEU A 266
ASP A 236
 None
None
None
RMN  A 401 (-2.8A)
 0.89A 2bxkA-4p56A:
undetectable		 2bxkA-4p56A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 GLY A 111
ASP A 112
SER A 116
 None
 0.62A 2qhfA-4p56A:
undetectable		 2qhfA-4p56A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 PHE A 164
PHE A 152
SER A 195
PHE A 229
 None
 1.13A 2v0mD-4p56A:
undetectable		 2v0mD-4p56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 ILE A  53
ALA A  56
ARG A 260
VAL A  87
ILE A 242
 None
 1.11A 3falA-4p56A:
undetectable		 3falA-4p56A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 VAL A  90
PHE A  99
LEU A 140
ILE A 143
 None
PGE  A 402 ( 4.5A)
None
None
 0.85A 3rfmA-4p56A:
undetectable		 3rfmA-4p56A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 6 THR A  88
ILE A 241
THR A 102
PHE A  99
 None
None
None
PGE  A 402 ( 4.5A)
 0.89A 4acbC-4p56A:
undetectable		 4acbC-4p56A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 GLU A 134
THR A 237
HIS A  92
 None
 0.87A 4q15A-4p56A:
undetectable		 4q15A-4p56A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 ASP A 278
HIS A 277
GLY A 271
ALA A 270
 None
 0.97A 5hwaA-4p56A:
undetectable		 5hwaA-4p56A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 HIS A 146
VAL A  41
GLY A 271
ALA A 273
 RMN  A 401 (-4.2A)
None
None
None
 0.95A 5hwaA-4p56A:
undetectable		 5hwaA-4p56A:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 TYR A  94
ARG A 170
PRO A 210
GLU A 212
 RMN  A 401 (-4.6A)
RMN  A 401 (-2.8A)
RMN  A 401 ( 4.4A)
RMN  A 401 ( 4.4A)
 0.95A 5im2A-4p56A:
40.9		 5im2A-4p56A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLU A 228
GLY A 147
PRO A 148
ASP A 278
 None
 1.10A 5kgpA-4p56A:
undetectable		 5kgpA-4p56A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLU A 228
GLY A 147
PRO A 148
ASP A 278
 None
 1.11A 5kgpB-4p56A:
undetectable		 5kgpB-4p56A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 GLU A 212
ASP A 278
HIS A 146
ALA A 145
GLY A 231
 RMN  A 401 ( 4.4A)
None
RMN  A 401 (-4.2A)
None
None
 1.29A 5syeB-4p56A:
undetectable		 5syeB-4p56A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 PRO A 193
SER A 213
VAL A  41
PHE A  99
PHE A  89
 None
RMN  A 401 (-2.5A)
None
PGE  A 402 ( 4.5A)
None
 1.03A 6behA-4p56A:
undetectable
6behB-4p56A:
undetectable
6behC-4p56A:
undetectable		 6behA-4p56A:
20.95
6behB-4p56A:
20.95
6behC-4p56A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 VAL A  90
PHE A  99
GLU A 134
LEU A 140
ILE A 143
 None
PGE  A 402 ( 4.5A)
None
None
None
 1.25A 6d9hR-4p56A:
undetectable		 6d9hR-4p56A:
11.11