SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLY A 109
TYR A 114
ASN A 135
TYR A 138
GLN A 163
HIS A 185
 2F6  A 301 (-3.6A)
None
None
None
2F6  A 301 (-3.8A)
None
 0.44A 1h1dA-4p58A:
33.1		 1h1dA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 4 SER A 115
GLU A 133
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.69A 1h1dA-4p58A:
33.1		 1h1dA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 ARG A 121
GLY A  90
ASP A  94
 None
 0.33A 1kf6A-4p58A:
2.0
1kf6B-4p58A:
undetectable		 1kf6A-4p58A:
16.44
1kf6B-4p58A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ASN A 135
GLN A 163
HIS A 185
 None
2F6  A 301 (-3.6A)
None
None
2F6  A 301 (-3.8A)
None
 0.44A 1vidA-4p58A:
33.0		 1vidA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 5 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.70A 1vidA-4p58A:
33.0		 1vidA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 GLY A 109
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
None
 0.19A 2b25B-4p58A:
15.5		 2b25B-4p58A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLY A 109
TYR A 114
ASN A 135
TYR A 138
SER A 162
HIS A 185
 2F6  A 301 (-3.6A)
None
None
None
2F6  A 301 (-3.2A)
None
 0.37A 2cl5A-4p58A:
33.8		 2cl5A-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ASN A 135
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
None
 0.55A 2cl5B-4p58A:
33.5		 2cl5B-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLU A 107
GLY A 109
TYR A 138
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
 0.92A 2cl5B-4p58A:
33.5		 2cl5B-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 6 GLU A 133
TYR A 138
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.52A 2cl5B-4p58A:
33.5		 2cl5B-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 6 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.70A 2cl5B-4p58A:
33.5		 2cl5B-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 8 LEU A 191
LEU A 195
LEU A 209
ALA A 253
 None
 0.78A 2vcvP-4p58A:
undetectable		 2vcvP-4p58A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		8 / 12 GLY A 109
TYR A 114
ASN A 135
TYR A 138
SER A 162
GLN A 163
HIS A 185
ARG A 189
 2F6  A 301 (-3.6A)
None
None
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 0.52A 2zthA-4p58A:
34.1		 2zthA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 115
GLU A 133
ASP A 184
 None
2F6  A 301 (-2.7A)
None
 0.69A 2zthA-4p58A:
34.1		 2zthA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ASN A 135
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
None
 0.53A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLU A 107
GLY A 109
TYR A 138
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
 1.02A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 6 GLU A 133
TYR A 138
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.61A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 6 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.74A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 MET A 145
GLU A 107
ASP A 212
 None
 0.91A 3a25A-4p58A:
13.5		 3a25A-4p58A:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLU A 107
TYR A 114
ASN A 135
SER A 162
GLN A 163
HIS A 185
ARG A 189
 None
None
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 0.62A 3a7eA-4p58A:
32.6		 3a7eA-4p58A:
81.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
TYR A 138
SER A 162
GLN A 163
HIS A 185
ARG A 189
 None
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 1.06A 3a7eA-4p58A:
32.6		 3a7eA-4p58A:
81.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 6 GLY A 109
SER A 115
GLU A 133
ILE A 134
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.7A)
None
 0.69A 3a7eA-4p58A:
32.6		 3a7eA-4p58A:
81.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLY A 109
TYR A 114
ILE A 134
ASN A 135
SER A 162
GLN A 163
HIS A 185
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.46A 3bwmA-4p58A:
33.6		 3bwmA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLY A 109
TYR A 138
SER A 162
GLN A 163
HIS A 185
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 1.11A 3bwmA-4p58A:
33.6		 3bwmA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 115
GLU A 133
ASP A 184
 None
2F6  A 301 (-2.7A)
None
 0.83A 3bwmA-4p58A:
33.6		 3bwmA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		8 / 12 GLU A 107
GLY A 109
TYR A 114
ILE A 134
SER A 162
GLN A 163
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 0.52A 3bwyA-4p58A:
33.7		 3bwyA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLU A 107
GLY A 109
TYR A 138
SER A 162
GLN A 163
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 1.06A 3bwyA-4p58A:
33.7		 3bwyA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 115
GLU A 133
ASP A 184
 None
2F6  A 301 (-2.7A)
None
 0.81A 3bwyA-4p58A:
33.7		 3bwyA-4p58A:
81.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 ASP A 248
VAL A 247
ILE A 215
GLY A 249
HIS A 236
 None
 1.06A 3hgiA-4p58A:
undetectable		 3hgiA-4p58A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 10 GLU A 107
GLY A 109
GLU A 133
SER A 162
GLN A 163
ASP A 184
 None
2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.41A 3s68A-4p58A:
33.3		 3s68A-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 10 GLY A 109
SER A 115
GLU A 133
SER A 162
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.72A 3s68A-4p58A:
33.3		 3s68A-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		8 / 12 TYR A 114
MET A 132
ASN A 135
TYR A 138
ALA A 161
PHE A 182
HIS A 185
ARG A 189
 None
None
None
None
2F6  A 301 (-4.1A)
None
None
None
 0.46A 3s68A-4p58A:
33.3		 3s68A-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 ILE A 157
LEU A 146
GLY A 109
THR A 142
GLY A 160
 None
None
2F6  A 301 (-3.6A)
None
None
 0.85A 3uq6B-4p58A:
3.9		 3uq6B-4p58A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 9 PRO A  65
GLY A 150
ALA A 149
ALA A 116
LEU A  69
 None
 1.38A 3ur0C-4p58A:
undetectable		 3ur0C-4p58A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 ILE A 157
LEU A 146
GLY A 109
THR A 142
GLY A 160
 None
None
2F6  A 301 (-3.6A)
None
None
 0.89A 3vaqB-4p58A:
4.9		 3vaqB-4p58A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 11 LEU A 197
VAL A 181
PHE A 222
ALA A 253
PHE A 232
 None
 1.44A 4evrA-4p58A:
undetectable		 4evrA-4p58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 GLU A  78
TYR A 243
GLU A 242
 None
 0.80A 4ryaA-4p58A:
undetectable		 4ryaA-4p58A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLY A 109
ALA A 110
ILE A 157
ILE A 159
THR A 142
 2F6  A 301 (-3.6A)
None
None
None
None
 0.93A 4xdrA-4p58A:
undetectable		 4xdrA-4p58A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ILE A 134
GLN A 163
HIS A 185
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
2F6  A 301 (-3.8A)
None
 0.34A 4xucA-4p58A:
33.2		 4xucA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 4 SER A 115
GLU A 133
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.76A 4xucA-4p58A:
33.2		 4xucA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLU A 107
GLY A 109
TYR A 114
ILE A 134
SER A 162
GLN A 163
HIS A 185
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.35A 4xudA-4p58A:
33.2		 4xudA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLU A 107
GLY A 109
TYR A 138
SER A 162
HIS A 185
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.2A)
None
 1.10A 4xudA-4p58A:
33.2		 4xudA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 115
GLU A 133
ASP A 184
 None
2F6  A 301 (-2.7A)
None
 0.75A 4xudA-4p58A:
33.2		 4xudA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 ILE A 134
ASN A 135
SER A 162
GLN A 163
HIS A 185
 2F6  A 301 (-3.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.45A 4xueA-4p58A:
33.5		 4xueA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 5 GLY A 109
TYR A 114
SER A 115
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
None
None
2F6  A 301 (-2.7A)
None
 0.69A 4xueA-4p58A:
33.5		 4xueA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLY A 109
TYR A 114
ILE A 134
ASN A 135
SER A 162
GLN A 163
HIS A 185
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.45A 4xueB-4p58A:
33.2		 4xueB-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLY A 109
TYR A 114
SER A 115
ILE A 134
ASN A 135
SER A 162
HIS A 185
 2F6  A 301 (-3.6A)
None
None
2F6  A 301 (-3.7A)
None
2F6  A 301 (-3.2A)
None
 0.65A 4xueB-4p58A:
33.2		 4xueB-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLY A 109
TYR A 138
SER A 162
GLN A 163
HIS A 185
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 1.13A 4xueB-4p58A:
33.2		 4xueB-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		9 / 12 GLU A 107
TYR A 114
MET A 132
ASN A 135
TYR A 138
ALA A 161
HIS A 185
ARG A 189
ASP A 193
 None
None
None
None
None
2F6  A 301 (-4.1A)
None
None
None
 0.46A 5fhqA-4p58A:
29.4		 5fhqA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHQ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 9 GLY A 109
GLU A 133
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.39A 5fhqA-4p58A:
29.4		 5fhqA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHQ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 9 GLY A 109
SER A 115
GLU A 133
SER A 162
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.72A 5fhqA-4p58A:
29.4		 5fhqA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ASN A 135
GLN A 163
HIS A 185
 None
2F6  A 301 (-3.6A)
None
None
2F6  A 301 (-3.8A)
None
 0.47A 5fhrA-4p58A:
29.6		 5fhrA-4p58A:
97.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 5 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.68A 5fhrA-4p58A:
29.6		 5fhrA-4p58A:
97.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHR_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 114
ASN A 135
TYR A 138
HIS A 185
 None
2F6  A 301 (-3.6A)
None
None
None
None
 0.37A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 5 GLU A 133
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.41A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 5 SER A 115
GLU A 133
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
2F6  A 301 (-3.2A)
None
 0.74A 5fhrB-4p58A:
29.5		 5fhrB-4p58A:
97.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLU A 107
GLY A 109
TYR A 114
ILE A 134
ASP A 184
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
None
 0.64A 5kvaA-4p58A:
20.6		 5kvaA-4p58A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 GLU A 107
GLY A 109
TYR A 114
ILE A 134
ASP A 184
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.7A)
None
 0.61A 5kvaB-4p58A:
20.6		 5kvaB-4p58A:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		7 / 12 GLU A 107
GLY A 109
ILE A 134
SER A 162
GLN A 163
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
2F6  A 301 (-3.7A)
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 0.55A 5lsaA-4p58A:
33.3		 5lsaA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 GLU A 107
GLY A 109
TYR A 138
SER A 162
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
2F6  A 301 (-3.2A)
None
None
 1.02A 5lsaA-4p58A:
33.3		 5lsaA-4p58A:
81.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 4 TYR A 114
SER A 115
GLU A 133
ASP A 184
 None
None
2F6  A 301 (-2.7A)
None
 0.75A 5lsaA-4p58A:
33.3		 5lsaA-4p58A:
81.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 GLY A 109
SER A 115
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
None
 0.70A 5n5dB-4p58A:
21.9		 5n5dB-4p58A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 MET A 145
GLN A  57
ALA A  60
LEU A  53
ILE A  52
 None
 1.48A 5vlmA-4p58A:
undetectable		 5vlmA-4p58A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 4p58 CATECHOL
O-METHYLTRANSFERASE
(Mus
musculus) 		4 / 4 GLN A 152
LEU A 146
ASN A 147
GLN A 143
 None
 1.25A 5vw3A-4p58A:
2.4		 5vw3A-4p58A:
22.11