SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		5 / 12 LEU A 190
LEU A 186
VAL A  74
ALA A 213
LEU A 177
 None
 1.05A 3r9cA-4p5bA:
undetectable		 3r9cA-4p5bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 8 LEU A 156
VAL A 168
LEU A 169
ALA A  97
 None
None
None
BRU  A 302 (-3.6A)
 0.95A 3uniB-4p5bA:
0.8		 3uniB-4p5bA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		5 / 11 ALA A 165
LEU A 169
GLY A 103
ILE A  78
LEU A 156
 None
None
SO4  A 303 ( 3.8A)
None
None
 1.04A 3zosA-4p5bA:
undetectable
3zosB-4p5bA:
undetectable		 3zosA-4p5bA:
22.19
3zosB-4p5bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 GLU A 229
GLY A  47
ARG A  50
LYS A  45
 None
 1.05A 4fgzA-4p5bA:
undetectable		 4fgzA-4p5bA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.34A 4tzuB-4p5bA:
undetectable
4tzuC-4p5bA:
undetectable		 4tzuB-4p5bA:
17.39
4tzuC-4p5bA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		3 / 3 VAL A 237
ALA A 199
PHE A 231
 None
 0.70A 4z4iA-4p5bA:
undetectable		 4z4iA-4p5bA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		3 / 3 VAL A 237
ALA A 199
PHE A 231
 None
 0.69A 5js1A-4p5bA:
undetectable		 5js1A-4p5bA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.38A 5yizG-4p5bA:
0.0
5yizY-4p5bA:
0.0		 5yizG-4p5bA:
14.52
5yizY-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.35A 5yizk-4p5bA:
undetectable
5yizt-4p5bA:
undetectable		 5yizk-4p5bA:
14.52
5yizt-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.41A 5yizk-4p5bA:
0.0
5yizt-4p5bA:
0.0		 5yizk-4p5bA:
14.52
5yizt-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.34A 5yizG-4p5bA:
0.0
5yizY-4p5bA:
0.0		 5yizG-4p5bA:
14.52
5yizY-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.35A 5yj0k-4p5bA:
0.0
5yj0t-4p5bA:
0.0		 5yj0k-4p5bA:
14.52
5yj0t-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.35A 5yj0G-4p5bA:
0.0
5yj0Y-4p5bA:
0.0		 5yj0G-4p5bA:
14.52
5yj0Y-4p5bA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 8 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.34A 5yj1G-4p5bA:
undetectable
5yj1Y-4p5bA:
undetectable		 5yj1G-4p5bA:
17.96
5yj1Y-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.34A 5yj1k-4p5bA:
0.0
5yj1t-4p5bA:
0.0		 5yj1k-4p5bA:
17.96
5yj1t-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 8 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.33A 5yj1k-4p5bA:
undetectable
5yj1t-4p5bA:
undetectable		 5yj1k-4p5bA:
17.96
5yj1t-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.34A 5yj1G-4p5bA:
undetectable
5yj1Y-4p5bA:
undetectable		 5yj1G-4p5bA:
17.96
5yj1Y-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		3 / 3 ARG A  86
HIS A  83
ARG A  82
 FAD  A 301 ( 2.9A)
None
None
 1.13A 6dwdD-4p5bA:
undetectable		 6dwdD-4p5bA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 6 ASP A 110
TYR A 107
GLU A 208
GLU A 214
 None
 0.95A 6mn5A-4p5bA:
undetectable		 6mn5A-4p5bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 ASP A 110
TYR A 107
GLU A 208
GLU A 210
 None
 1.02A 6mn5E-4p5bA:
undetectable		 6mn5E-4p5bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p5b THYMIDYLATE SYNTHASE
THYX
(Streptomyces
cacaoi) 		4 / 7 ASP A 110
TYR A 107
GLU A 208
GLU A 214
 None
 0.96A 6mn5E-4p5bA:
undetectable		 6mn5E-4p5bA:
16.74