SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 12 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.32A 1q23B-4p5eA:
undetectable		 1q23B-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 12 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.32A 1q23C-4p5eA:
undetectable		 1q23C-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 10 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.37A 1q23E-4p5eA:
undetectable		 1q23E-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 11 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.36A 1q23I-4p5eA:
undetectable		 1q23I-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 11 ARG A 120
SER A 123
GLN A  96
VAL A 101
CYH A  26
 None
None
None
N6P  A 201 ( 4.6A)
N6P  A 201 (-4.8A)
 1.39A 2a5hA-4p5eA:
undetectable		 2a5hA-4p5eA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 12 ARG A 120
SER A 123
GLN A  96
VAL A 101
CYH A  26
 None
None
None
N6P  A 201 ( 4.6A)
N6P  A 201 (-4.8A)
 1.42A 2a5hB-4p5eA:
1.8		 2a5hB-4p5eA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 12 ARG A 120
SER A 123
GLN A  96
VAL A 101
CYH A  26
 None
None
None
N6P  A 201 ( 4.6A)
N6P  A 201 (-4.8A)
 1.40A 2a5hC-4p5eA:
1.8		 2a5hC-4p5eA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 12 ARG A 120
SER A 123
GLN A  96
VAL A 101
CYH A  26
 None
None
None
N6P  A 201 ( 4.6A)
N6P  A 201 (-4.8A)
 1.40A 2a5hD-4p5eA:
1.8		 2a5hD-4p5eA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		4 / 8 VAL A  94
LEU A  84
GLY A 106
ALA A 108
 None
 0.85A 2xfsA-4p5eA:
undetectable		 2xfsA-4p5eA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		4 / 8 VAL A  94
LEU A  84
GLY A 106
ALA A 108
 None
 0.85A 2xh9A-4p5eA:
undetectable		 2xh9A-4p5eA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		5 / 11 ASP A 155
PHE A 158
LEU A 163
LEU A 116
ILE A  42
 None
 1.22A 6fgcA-4p5eA:
2.7		 6fgcA-4p5eA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens) 		4 / 7 TYR A 145
GLU A  93
ASP A  35
GLU A  34
 None
 1.37A 6mn5E-4p5eA:
undetectable		 6mn5E-4p5eA:
21.09