SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 4 ARG A 185
GLY A 183
GLU A 181
SER A 154
 None
 1.03A 2xctS-4p5hA:
undetectable
2xctU-4p5hA:
undetectable		 2xctS-4p5hA:
17.68
2xctU-4p5hA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 VAL A  81
TYR A 136
TYR A 156
ILE A 108
 None
 1.25A 2xz5B-4p5hA:
undetectable
2xz5E-4p5hA:
undetectable		 2xz5B-4p5hA:
20.68
2xz5E-4p5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 8 ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.28A 2xz5A-4p5hA:
undetectable
2xz5C-4p5hA:
undetectable		 2xz5A-4p5hA:
20.68
2xz5C-4p5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.27A 2xz5D-4p5hA:
undetectable
2xz5E-4p5hA:
undetectable		 2xz5D-4p5hA:
20.68
2xz5E-4p5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 ALA A 302
TYR A 312
ILE A 258
HIS A 285
 None
 1.15A 2zm7A-4p5hA:
undetectable		 2zm7A-4p5hA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 12 TYR A 251
ILE A 253
VAL A 287
PHE A 316
TYR A 296
 None
 1.44A 3a8iD-4p5hA:
undetectable		 3a8iD-4p5hA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 1.24A 3k9fA-4p5hA:
undetectable
3k9fB-4p5hA:
undetectable
3k9fC-4p5hA:
undetectable		 3k9fA-4p5hA:
20.50
3k9fB-4p5hA:
20.50
3k9fC-4p5hA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 12 ASP A 201
LYS A 237
VAL A  43
ILE A  44
ILE A 142
 None
 1.14A 3kpdB-4p5hA:
undetectable		 3kpdB-4p5hA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 12 GLY A  34
GLY A  37
SER A 277
TYR A 264
ASN A 262
 None
 1.37A 3t7sC-4p5hA:
undetectable		 3t7sC-4p5hA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.31A 4afgA-4p5hA:
undetectable
4afgB-4p5hA:
undetectable		 4afgA-4p5hA:
22.62
4afgB-4p5hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 ILE A  96
ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.34A 4afgA-4p5hA:
undetectable
4afgE-4p5hA:
undetectable		 4afgA-4p5hA:
22.62
4afgE-4p5hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 8 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.28A 4afgD-4p5hA:
undetectable
4afgE-4p5hA:
undetectable		 4afgD-4p5hA:
22.62
4afgE-4p5hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.32A 4afgC-4p5hA:
0.0
4afgD-4p5hA:
0.0		 4afgC-4p5hA:
22.62
4afgD-4p5hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.35A 4afgB-4p5hA:
0.0
4afgC-4p5hA:
0.0		 4afgB-4p5hA:
22.62
4afgC-4p5hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 8 VAL A  81
TYR A 136
TYR A 156
ILE A 108
 None
 1.23A 4bqtC-4p5hA:
undetectable
4bqtD-4p5hA:
undetectable		 4bqtC-4p5hA:
20.68
4bqtD-4p5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		3 / 3 ASP A  39
TRP A 234
SER A 150
 None
 1.05A 4lrhF-4p5hA:
undetectable		 4lrhF-4p5hA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 ARG A 185
GLY A 183
GLU A 181
SER A 154
 None
 1.05A 4z3oA-4p5hA:
undetectable
4z3oB-4p5hA:
undetectable		 4z3oA-4p5hA:
17.92
4z3oB-4p5hA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 6 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 1.05A 5btcA-4p5hA:
undetectable
5btcC-4p5hA:
undetectable
5btcD-4p5hA:
undetectable		 5btcA-4p5hA:
18.58
5btcC-4p5hA:
18.58
5btcD-4p5hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 6 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 1.08A 5btcA-4p5hA:
undetectable
5btcB-4p5hA:
undetectable
5btcC-4p5hA:
undetectable		 5btcA-4p5hA:
18.58
5btcB-4p5hA:
21.05
5btcC-4p5hA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 1.11A 5btfA-4p5hA:
undetectable
5btfC-4p5hA:
undetectable
5btfD-4p5hA:
undetectable		 5btfA-4p5hA:
18.58
5btfC-4p5hA:
18.58
5btfD-4p5hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 0.93A 5cdqA-4p5hA:
undetectable
5cdqB-4p5hA:
undetectable
5cdqC-4p5hA:
undetectable		 5cdqA-4p5hA:
21.83
5cdqB-4p5hA:
20.79
5cdqC-4p5hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
 0.92A 5cdqR-4p5hA:
undetectable
5cdqS-4p5hA:
undetectable
5cdqT-4p5hA:
undetectable		 5cdqR-4p5hA:
21.83
5cdqS-4p5hA:
20.79
5cdqT-4p5hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4p5h CLAUDIN-2
HEAT-LABILE
ENTEROTOXIN B CHAIN
(Mus
musculus;
Clostridium
perfringens) 		5 / 10 TYR A 139
ASP A  45
ASP 1 154
GLY A  47
THR A 107
 None
 1.29A 6mn1A-4p5hA:
undetectable		 6mn1A-4p5hA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4p5h CLAUDIN-2
HEAT-LABILE
ENTEROTOXIN B CHAIN
(Mus
musculus;
Clostridium
perfringens) 		5 / 10 TYR A 139
ASP A  45
ASP 1 154
GLY A  47
THR A 107
 None
 1.29A 6mn1B-4p5hA:
undetectable		 6mn1B-4p5hA:
16.83